PROFOXYDIM-LITHIUM
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- CAS-Nr.
- 139001-49-3
- Englisch Name:
- PROFOXYDIM-LITHIUM
- Synonyma:
- AIK;AURA;STK7;BTAK;STK6;ARK1;AIRK1;AURKA;STK15;TETRIS
- CBNumber:
- CB4320465
- Summenformel:
- C24H32ClNO4S
- Molgewicht:
- 466.03
- MOL-Datei:
- 139001-49-3.mol
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PROFOXYDIM-LITHIUM Eigenschaften
- Schmelzpunkt:
- <25 °C
- Siedepunkt:
- 597.2±60.0 °C(Predicted)
- Dichte
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -70°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 4.25±0.25(Predicted)
- Farbe
- White to Off-White
- Stabilität:
- Hygroscopic, Unstable in Solution
- EPA chemische Informationen
- Profoxydim (139001-49-3)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
21/22 |
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| S-Sätze: |
36/37 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P333+P313 |
Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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PROFOXYDIM-LITHIUM Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
G-protein-coupled receptor kinase 2 (GRK2), which is officially known as adrenergic, beta, receptor kinase 1 (ADRBK1), gene codes for a 689 amino acid protein, that is of 79.573kDa. This gene has 12 catalytic region subdomains. GRK2 is expressed in the vascular endothelium, arterial smooth muscle, myocardium, kidney and in the renal proximal tubule. It is mapped to human chromosome 11q13.
Biochem/physiol Actions
G-protein-coupled receptor kinase 2 (GRK2) or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2. After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. G-protein-coupled receptor kinase 2 (GRK2) controls several intracellular mechanisms. It helps to maintain the structure and activities of the heart. Hence it participates in several cardiovascular diseases. GRK2 also modulates ion and fluid transport and eventually, blood pressure. It increases the synthesis of mitochondrial superoxide and reduces oxygen utilization and ATP synthesis. This protein serves as a major onco-modulator.
PROFOXYDIM-LITHIUM Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PROFOXYDIM-LITHIUM Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 56)Lieferanten
139001-49-3()Verwandte Suche:
- CLEFOXYDIM
- (5RS)-2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-[(3RS)-thian-3-yl]cyclohex-2-en-1-one
- TETRIS
- PROFOXYDIM
- PROFOXYDIM-LITHIUM
- PROFOXYDIM LITHIUM SALT
- BAS625H
- AURA
- CLEFOXYDIM LITHIUM SALT
- Aurora Kinase A active human
- GRK2, active, GST tagged human
- Anti-Aurora Kinase antibody produced in rabbit
- ANTI-AIK(N-TERMINAL) antibody produced in rabbit
- AURORA A, active, GST tagged from mouse
- MGC34538
- STK7
- BTAK
- Monoclonal Anti-AURKA antibody produced in mouse
- STK6
- AIK
- AIRK1
- ANTI-AURORA-A(C-TERMINAL) antibody produced in rabbit
- ARK1
- AURKA
- Anti-AURA, C-Terminal antibody produced in rabbit
- Aurora-A
- Aurora-family kinase 1
- Aurora-related kinase 1
- AURORA A, active, GST tagged human
- STK15
- Anti-Serine/threonine protein kinase 15
- AntiSTK15 (Serine/threonine protein kinase 15)
- 2-Cyclohexen-1-one, 2-[1-[[2-(4-chlorophenoxy)propoxy]imino]butyl]-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)-
- 139001-49-3
- C24H31ClNO4SLi
