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2'-Deoxy-L-thymidine

2'-Deoxy-L-thymidine Struktur
3424-98-4
CAS-Nr.
3424-98-4
Englisch Name:
2'-Deoxy-L-thymidine
Synonyma:
Ldt;L-Dt;Sebivo;NV 02B;Epavudine;Aids112549;elbivudine;Aids-112549;L-Deoxythymidine;BETA-L-THYMIDINE
CBNumber:
CB4321891
Summenformel:
C10H14N2O5
Molgewicht:
242.23
MOL-Datei:
3424-98-4.mol
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2'-Deoxy-L-thymidine Eigenschaften

Schmelzpunkt:
188-190°C
alpha 
D20 -20.3° (c = 0.192 in water)
Dichte
1.452±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
H2O: soluble10mg/mL (clear solution)
pka
9.55±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Optische Aktivität
[α]/D -15 to -22°, c = 1 in H2O
InChIKey
IQFYYKKMVGJFEH-CSMHCCOUSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
S-Sätze: 24/25
WGK Germany  3
RTECS-Nr. UV9048500
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2'-Deoxy-L-thymidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Telbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.

Chemische Eigenschaften

2'-Deoxy-L-thymidine is White Solid

Definition

ChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.

2'-Deoxy-L-thymidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2'-Deoxy-L-thymidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 305)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578
 sales@hbmojin.com China 12456 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293
 sales@sdzschem.com China 2931 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 6992 58
Beijing Ribio Biotech Co.,Ltd 		010-62664360 +8613328773880
 wucy@ribio.com.cn China 117 58
Yunbio Tech Co.,Ltd. 		+86-010-60605551 +86-18046518538
 yunbiochem@126.com China 321 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282
 alice@crovellbio.com China 8823 58

3424-98-4()Verwandte Suche:

3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure Thymidine Zidovudine DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Deoxidizer Deoxynucleotide
  • 2'-Deoxy-L-thyMidine(Telbivudine)
  • Telbivudine(Tyzeka, Sebivo)
  • 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-
  • Telbivudine(L-ThyMidine,LDT-600)
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • 2,4(1H,3H)-PyriMidinedione,1-(2-deoxy-b-L-erythro-pentofuranosyl)-5-Methyl-
  • Sebivo
  • Telbivudine(L-ThyMidine)
  • Telbivudine, >=98%
  • 1-(2-Deoxy--L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
  • 1-(2-deoxy--L-erythro-pentofuranosyl)thymine
  • Epavudine
  • NV 02B
  • Aids112549
  • Aids-112549
  • L-Deoxythymidine
  • Ldt
  • L-Dt
  • Thymine, 1-(2-deoxy-.beta.-L-erythro-pentofuranosyl)-
  • BETA-L-THYMIDINE
  • 2'-DEOXY-L-THYMIDINE
  • L-Thymidine(Telbivudine)
  • 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
  • Β-L-2'-DEOXY-THYMIDINE
  • 1-[(2S,4R,5S)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methyl-
  • elbivudine
  • 2'-Deoxy-L-thymidine USP/EP/BP
  • Telbivudine (Epavudine)
  • Telbivudine 13C 15N2
  • Inhibitor,Telbivudine,inhibit,HBV,Hepatitis B virus
  • 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 2'-Deoxy-L-thymidine
  • 3424-98-4
  • Anti-virals
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • API intermediates
  • Amines
  • API
  • Chiral Reagents
  • Heterocycles
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