Losartan carboxylic acid
|
|
|
- CAS-Nr.
- 124750-92-1
- Englisch Name:
- Losartan carboxylic acid
- Synonyma:
- exp3174;Losartan Carboxylic Acid;e-3174;LOSARTAN CARBOXY ACID;EXP 317;l-158641;AKOS 91941;ALSTint-A07;Losartan acid;E-3174, EXP-3174
- CBNumber:
- CB4399601
- Summenformel:
- C22H21ClN6O2
- Molgewicht:
- 436.89
- MOL-Datei:
- 124750-92-1.mol
|
Losartan carboxylic acid Eigenschaften
- Schmelzpunkt:
- 130-132°C
- Siedepunkt:
- 707.8±70.0 °C(Predicted)
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- Dimethylformamide, Dimethyl Sulfoxide, Methanol
- Aggregatzustand
- Solid
- pka
- 0.79±0.50(Predicted)
- Farbe
- Light-Yellow
- InChIKey
- ZEUXAIYYDDCIRX-UHFFFAOYSA-N
- SMILES
- C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
|
|
| HS Code |
29339900 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
|
|
P201, P260, P263, P264, P270,P308+P313 |
|
| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
Losartan carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT
1 antagonist (K
is = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation
in vitro.
Chemische Eigenschaften
Light-Yellow Solid
Verwenden
Losartan carboxylic acid is used as a metabolite of Losartan.
Definition
ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.
Losartan carboxylic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Losartan carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 152)Lieferanten
124750-92-1()Verwandte Suche:
- AKOS 91941
- 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
- ’-biphenyl)-4-yl)methyl)-
- 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1
- 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
- 1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid
- EXP 317
- Losartan Carboxylic Acid Discontinued see product # L470510
- l-158641
- EXP 3174 (LOSARTAN CARBOXYLIC ACID)
- 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-carboxylic acid
- 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic acid
- 2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid
- 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
- Losartan Carboxylic Acid
NEW CATALOGUE NUMBER: see product # L470510
- Losartan acid
- Losartan carboxylic acid, >=98%
- 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formic acid
- LOSARTAN,2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
- Losartan Impurity 14
- 1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
- 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1
- E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1;1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID
- Losartan Carboxylic Acid USP/EP/BP
- 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID USP/EP/BP
- Losartan Carboxylic Acid (Losartan Carboxylate)
- Losartan Carboxylic acid Impurity
- Losartan carboxylic acidQ: What is
Losartan carboxylic acid Q: What is the CAS Number of
Losartan carboxylic acid Q: What is the storage condition of
Losartan carboxylic acid Q: What are the applications of
Losartan carboxylic acid
- 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
- ALSTint-A07
- 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid
- E-3174, EXP-3174
- 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
- E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174
- LOSARTAN CARBOXY ACID
- Losartan Carboxylic Acid
- e-3174
- exp3174
- 124750-92-1
- C22H21ClN6O2
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Heterocycles
