Pentagastrin

Pentagastrin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R61:Kann das Kind im Mutterleib schädigen.
R36/38:Reizt die Augen und die Haut.
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Beschreibung

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK₂) receptor agonist. It binds selectively to CCK₂ receptors in guinea pig brain over CCK₁ receptors in rat pancreas (IC₅₀s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC₅₀s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC₅₀ = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC₅₀ = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED₅₀s = 1.29 and 57.3 nmol/kg² per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemische Eigenschaften

A white or almost white powder.

Verwenden

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Allgemeine Beschreibung

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH₂), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Pentagastrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pentagastrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shanghai Getian Industrial Co., LTD	+undefined15373193816	mike@ge-tian.com	China	272	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
Rixing Chemical CO.,LTD	+86-13237129059 -13237129059	sales@rixingchemi.com	CHINA	229	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9553	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58

5534-95-2(Pentagastrin)Verwandte Suche:

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• T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
• aspartyl]-l-phenylalaninamide
• ay6608
• boc-beta-ala-try-met-asp-phe(nh2)
• gastrodiagnost
• ici50123
• lanineamide
• l-methionyl-l-alpha-aspartyl-
• l-n-tert-butyleste
• n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid
• petogasrin
• -tert-butylester
• ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester
• n-t-boc-β-ala-trp-met-asp-phe amide
• N-T-boc-B-ala-trp-met-asp-phe amide
• PENTAGASTRIN (ICI 50123) SYNTHETIC >99%
• BOC-β-Ala-Trp-Met-Asp-Phe-NH2
• N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
• N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
• AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4
• Boc-b-Ala-Trp-Met-Asp-Phe-NH2
• n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-
• n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l-
• n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid
• n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden
• n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla
• peptavlon
• petavlon
• Boc-(β-Ala13)-Gastrin (13-17)
• GRP
• GASTRIN RELEASING PEPTIDE
• BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
• PENTAGASTRIN
• N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE
• Acetyl-L-glutamic acid &gamma
• Z-N-methyl-L-glutamic acid &gamma
• N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha
• Fmoc-L-alpha-aminoadipic acid &delta
• Fmoc-N-methyl-L-glutamic acid &gamma
• Methotrexate &alpha
• 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI)
• L-Glutamic Acid &alpha
• DL-Glutamic acid &gamma
• N-tert-Butyloxycarbonyl-L-aspartic Acid &beta
• Pentagastrin, ≥95%(HPLC)
• Z-L-beta-Glutamic acid &gamma
• Fmoc-L-aspartic Acid &beta
• Pehtagastrin
• L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• PENTAGASTRIN USP/EP/BP
• Boc-(β-Ala13)-Gastrin (13-17)
• 5534-95-2
• C37H49N7O9S
• C37H50N7O9S
• Gastrointestinal Products
• Cholecystokinins
• Peptides
• Amino Acids and Peptides