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Calcipotriene Produkt Beschreibung

Calcipotriene Struktur
112965-21-6
CAS-Nr.
112965-21-6
Englisch Name:
Calcipotriene
Synonyma:
mc903;dovonex;Daivonex;Daivobet;Calciptriol;Calcipotriene;Calcipotriene-d4;CALCIPOTRIOL - EP;5z,7e,22e,24s)--bet;Calcipotriol hydrate
CBNumber:
CB4412713
Summenformel:
C27H40O3
Molgewicht:
412.6
MOL-Datei:
112965-21-6.mol

Calcipotriene Eigenschaften

Schmelzpunkt:
166-168°C
Siedepunkt:
582.0±50.0 °C(Predicted)
Dichte
1.12±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
Löslichkeit
DMSO: soluble15mg/mL, clear
pka
14.29±0.20(Predicted)
Aggregatzustand
powder
InChIKey
LWQQLNNNIPYSNX-HCHVWAPNSA-N
CAS Datenbank
112965-21-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2906195000

Calcipotriene Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Calcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.

Chemische Eigenschaften

White Crystalline Solid

Originator

Leo Denmark (Denmark)

Verwenden

An antipsoriatic. A vitamin D3 analogue with low calcemic activity

Verwenden

antipsoriatic;viamin D receptor (VDR) affinity

Verwenden

A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.

Indications

Calcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.

Trademarks

Dovonex (Leo);Daivonex.

Biologische Aktivität

Vitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Pharmakologie

Calcipotriene (Dovonex) enhances the effectiveness of ultraviolet B (UVB) but also increases photosensitivity in UVB-treated patients. Ultraviolet light, 6% salicylic acid, 12% lactic acid, hydrocortisone valerate 0.2% ointment, and tazarotene (Tazorac) gel degrade calcipotriene (Dovonex). Halobetasol ointment and 5% tar gel are compatible with Calcipotriene (Dovonex). A British study found calcipotriene (Dovonex) to be safe and effective in a pediatric population over the age of 3, although it is not approved by the FDA.

Calcipotriene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Calcipotriene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 150)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

112965-21-6()Verwandte Suche:


  • (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-Cyclopropyl-4-hydroxy-1-methylbut-2-en-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]-ethylidene]-4-methylene-1,3-cyclohexanediol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,1R,4S)-4-cyclopropyl-4-hydroxy-1-methyl-but-2-enyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • Calcipotriol-d4 (Calcipotriene-d4)
  • CALCIPOTRIOL - EP
  • (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2S)-5-cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
  • 24-CYCLOPROPYL-(1ALPHA,3BETA,5Z,7E,22E,24S)-9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL
  • 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1-alpha,3-beta,5Z,7E,22E,24S)
  • (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetrene-1α,3β,24-triol
  • 1α,24(OH)2-22-Ene-24-cyclopropyl-D3
  • Calcipotriol hydrate
  • Calcipotriol hydrate, Calcipotriene
  • 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
  • Calcipotriene-d4
  • (1S,3R,5Z)-5-{2-[(1R,3aR,4Z,7aS)-1-[(2R,3E,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-Methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-Methylidenecyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-Cyclopropyl-4-hydroxy-1-Methyl-2-buten-1-yl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-4-Methylene-1,3-cyclohexanediol
  • Calcipotriol(MC 903)
  • Calcipotriol anhydrous
  • 5z,7e,22e,24s)--bet
  • 9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol,24-cyclopropyl-,(1-alpha,3
  • dovonex
  • mc903
  • CALCIPOTRIOL,CALCIPOTRIENE
  • Calciptriol, MC-903, Daivonex, Dovonex, Psorcutan
  • Daivonex
  • Daivobet
  • Calciptriol
  • 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1α,3β,5Z,7E,22E,24S)-
  • calcipotriol anhydre ep5.3
  • Calcipotriene
  • (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • 112965-21-6
  • 112905-21-6
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotope Labelled Compounds
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