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Pramlintide acetate Produkt Beschreibung

Pramlintide acetate Struktur
196078-30-5
CAS-Nr.
196078-30-5
Englisch Name:
Pramlintide acetate
Synonyma:
pramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
CBNumber:
CB4468518
Summenformel:
C173H273N51O56S2
Molgewicht:
4027.46
MOL-Datei:
196078-30-5.mol

Pramlintide acetate Eigenschaften

Sicherheit

Pramlintide acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.

Chemische Eigenschaften

Pramlintide acetate is White Solid

Originator

Amylin (US)

Verwenden

Pramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.

Trademarks

Symlin (Amylin).

Pramlintide acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pramlintide acetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 109)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD.
18315825527
kevin@tianmapharma.com CHINA 19 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58

196078-30-5()Verwandte Suche:


  • AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
  • pramlintide acetate
  • pramlintide acetate hydrate
  • Pramlintide Acetate, Amylin Rat
  • 25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate
  • AC-137 Acetate Hydrate, SyMlin Acetate Hydrate
  • Tripo-aMylin Acetate Hydrate
  • 196078-30-5
  • C2H4O2C2H6C6H14N2OC15H27N5O7C144H222N42O43H2O
  • C171H267N51O53S2xC2H4O2xH2O
  • C171H267N51O53S2
  • C171H267N51O53S2xC2H4
  • Peptide
  • Amino Acids & Derivatives
  • Bases & Related Reagents
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
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