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Pramlintide acetate Produkt Beschreibung

Pramlintide acetate Struktur
196078-30-5
CAS-Nr.
196078-30-5
Englisch Name:
Pramlintide acetate
Synonyma:
pramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
CBNumber:
CB4468518
Summenformel:
C173H273N51O56S2
Molgewicht:
4027.46
MOL-Datei:
196078-30-5.mol

Pramlintide acetate Eigenschaften

Sicherheit

Pramlintide acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.

Chemische Eigenschaften

Pramlintide acetate is White Solid

Originator

Amylin (US)

Verwenden

Pramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.

Trademarks

Symlin (Amylin).

Clinical Use

Pramlintide acetate is a synthetic analogue of amylin (a 37-peptide) with proline substitutions at residues 25, 28, and 29. These substitutions change its physical properties such that it is commercially available for SC injection. When pramlintide is used in combination with insulin, it slows gastric emptying, lowers blood glucose levels after meals, and affords a feeling of fullness that leads to decreased caloric intake and the potential for weight loss. Pramlintide has been approved for use in adults with type I or type II diabetes as an adjunct along with insulin. The dose is quite different for type I (15–60 μg SC before meals) and type II diabetes (60–120 μg). The drug should be refrigerated before opening and may be kept at room temperature for up to 28 days after opening.

Pramlintide acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pramlintide acetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 115)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD.
18315825527
kevin@tianmapharma.com CHINA 19 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58

196078-30-5()Verwandte Suche:


  • AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
  • pramlintide acetate
  • pramlintide acetate hydrate
  • Pramlintide Acetate, Amylin Rat
  • 25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate
  • AC-137 Acetate Hydrate, SyMlin Acetate Hydrate
  • Tripo-aMylin Acetate Hydrate
  • 196078-30-5
  • C171H267N51O53S2xC2H4
  • C171H267N51O53S2xC2H4O2xH2O
  • C171H267N51O53S2
  • C2H4O2C2H6C6H14N2OC15H27N5O7C144H222N42O43H2O
  • Amino Acids & Derivatives
  • Bases & Related Reagents
  • Drug Analogues
  • Heterocycles
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  • Peptide
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