MERBARONE

97534-21-9

CAS-Nr.: 97534-21-9

Englisch Name:: MERBARONE

Synonyma:: RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide

CBNumber:: CB4494665

Summenformel:: C11H9N3O3S

Molgewicht:: 263.27

MOL-Datei:: 97534-21-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 36

MERBARONE Eigenschaften

Dichte: 1.51±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: >5mg/mL

Aggregatzustand: solid

pka: -2.16±0.20(Predicted)

Sicherheit

WGK Germany	3
RTECS-Nr.	UV7714625

MERBARONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Allgemeine Beschreibung

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 μM for purified mammalian topo II versus IC₅₀ = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Biochem/physiol Actions

Cell permeable: yes

MERBARONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MERBARONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 36)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	9944	58
Shanghai Naiys Biological Technology Co., Ltd	18321139117	316441092@qq.con	China	3005	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shanghai Tachizaki Biomedical Research Center	18014399201	sales@chemlab-tachizaki.com	China	2487	58
Jinan Sanbao Biotechnology Co., Ltd.	13854185395; 13854185395	sanbaobiotech@126.com	China	7998	58

5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
NSC-336628
hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
MERBARONE
4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
Merbarone - CAS 97534-21-9 - Calbiochem
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
RLBN1001
RLBN-1001
97534-21-9
Reagents
Tools for Gene Regulation Research
Gene Regulation and Expression
Cell Biology
Cell Signaling and Neuroscience
BioChemical