Tolbutamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Definition
ChEBI: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Allgemeine Beschreibung
Tolbutamide is N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide;or 1-butyl-3-(p-tolylsulfonyl)urea (Orinase,generic). Orinase Diagnostic was the sodium salt, which isfreely soluble in water for injection, but this product was discontinuedc. 2000.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLBUTAMIDE is incompatible with acids. .
Brandgefahr
Flash point data for TOLBUTAMIDE are not available. TOLBUTAMIDE is probably combustible.
Mechanism of action
Tolbutamide is one of the most widely used antidiabetic agents. Its action is preferably
connected with stimulatory action of β-cells in the pancreas, which results in intensive
insulin secretion.
Clinical Use
Tolbutamide should be used only when the diabetic patientis an adult or shows adult-onset diabetes, and the patientshould adhere to dietary restrictions.
Sicherheitsprofil
Moderately toxic by
ingestion and several other routes. A human
teratogen. Human reproductive effects by
ingestion and possibly other routes:
stillbirth, developmental abnormalities of
the cardlovascular (circulatory) system and
urogenital system, and unspecified neonatal
effects. Human systemic effects by
ingestion: nausea or vomiting, hypoglycemia.
Other experimental teratogenic and
reproductive effects. Mutation data
reported. Implicated in aplastic anemia.
When heated to decomposition it emits very
toxic fumes of NO, and SOx.
Tolbutamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
