S-Ethyl-1-perhydroazepinthioat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R43:Sensibilisierung durch Hautkontakt möglich.
R48/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S46:Bei Verschlucken sofort ärztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Verwenden
Selective herbicide used to control the germination of annual grasses and broadleaved
weeds in rice crops.
Allgemeine Beschreibung
Clear liquid with aromatic odor. Non corrosive. Used as an herbicide.
Air & Water Reaktionen
Water soluble. Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.
Reaktivität anzeigen
Molinate is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.
Landwirtschaftliche Anwendung
Herbicide: Molinate is a selective herbicide used on rice for the
control of water grass and other weeds.
Handelsname
ARROSOLO®; FELAN®; HIGALNATE®;
HYDRAM®; JALAN®; MALERBANE-GIAVONI-L®;ORDAM®; ORDRAM®; R-4572®; RICECO;
SAKKIMOL®; STAUFFER R 4,572®; YALAN®; YULAN®
Environmental Fate
Soil. Hydrolyzes in soil forming ethyl mercaptan, carbon dioxide and dialkylamine
(half-life approximately 2–5 weeks) (Hartley and Kidd, 1987). At recommended rates of
application, the half-life of molinate in moist loam soils at 21–27°C is approximately 3
weeks (Humburg et al., 1989). Rajagopal et al. (1989) reported that under flooded conditions,
molinate was hydroxylated at the 3- and 4-position with subsequent oxidation
forming many compounds including molinate sulfoxide, carboxymethyl molinate, hexahydroazepine-
1-carbothioate, 4-hydroxymolinate, 4-hydroxymolinate sulfoxide, hexahydroazepine,
S-methyl hexahydroazepine-1-carbothioate, 4-ketomolinate, 4-hydroxyhexahydroazepine,
4-hydroxy-N-acetyl-hexahydroazepine, carbon dioxide and bound
residues.
Plant. Molinate is rapidly metabolized by plants releasing carbon dioxide and naturally
occurring plant constituents (Humburg et al., 1989).
Photolytic. Molinate in a hydrogen peroxide solution (120 mM) was irradiated by UV
light (l = 290 nm) at 23°C. The major photooxidation products were the two isomers of
2-oxomolinate (20% yield) and s-molinate oxide (5% yield) (Draper and Crosby, 1984).
Half-lives of 180 and 120 hours were observed using one and two equivalents of hydrogen
peroxide, respectively (Draper and Crosby, 1984). Molinate has a UV absorption maximum
at 225 nm and no absorption at wavelengths >290 nm. Therefore, molinate is not expected
to undergo aqueous photolysis under natural sunlight (l = 290 nm). In the presence of
tryptophan, a naturally occurring photosensitizer, molinate in aqueous solution photodegraded
to form 1-((ethylsulfinyl)carbonyl)hexahydro-1H-azepine, S-ethyl hexahydro-2-
oxo-1H-azepine-1-carbothioate and hexamethyleneimine (Soderquist et al., 1977).
Chemical/Physical. Metabolites identified in tap water were molinate sulfoxide, 3- and
4-hydroxymolinate, ketohexamethyleneimine and 4-ketomolinate (Verschueren, 1983).
Stoffwechselwegen
Juvenile white sturgeon and common carp are
exposed to 14C-molinate in a flow-through metabolism
system and oxidize molinate to form several products
and hydrolyze or conjugate with glutathione (GSH),
the sulfoxide, or sulfone. Both fish form a D-glucuronic
acid conjugate. The higher toxicity of molinate in
common carp may be due to greater bioconcentration,
slower depuration, and less efficient metabolic
deactivation. In the blood of common carp, molinate is
oxidized by erythrocytes to the sulfoxide and possibly
the sulfone, then conjugated with GSH or cysteine and
cleaved to form mercapturic acid in both erythrocytes
and plasma. Conjugation and possible hemoglobin
carbamylation occur only after sulfoxidation of
molinate. Molinate is distributed uniformly throughout
the soil layers, and its degradation products are identified as 2-oxomolinate, 4-oxomolinate, molinate
acid, and hexamethyleneimine. In rice plants,
4-hydroxymolinate, 2-oxomolinate, 4-oxomolinate,
S-ethyl-N-carboxymethylthiocarbamate, molinate acid,
and molinate alcohol are detected. By the soil
microorganisms, oxidation of the S-ethyl moiety is
considered to be the main pathway, and hydroxy and
oxoderivatives on the azepine ring are identified.
S-Ethyl-1-perhydroazepinthioat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
