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Folsure Produkt Beschreibung

Folic acid Struktur
59-30-3
CAS-Nr.
59-30-3
Bezeichnung:
Folsure
Englisch Name:
Folic acid
Synonyma:
PGA;Folan;folic;Aspol;FOLSAN;Folate;Folbal;Folsav;VM/PGA;PTEGLU
CBNumber:
CB5100903
Summenformel:
C19H19N7O6
Molgewicht:
441.4
MOL-Datei:
59-30-3.mol

Folsure Eigenschaften

Schmelzpunkt:
250 °C
alpha 
20 º (c=1, 0.1N NaOH)
Siedepunkt:
552.35°C (rough estimate)
Dichte
1.4704 (rough estimate)
Brechungsindex
1.6800 (estimate)
storage temp. 
2-8°C
Löslichkeit
boiling water: soluble1%
pka
pKa 2.5 (Uncertain)
Aggregatzustand
Crystalline Powder
Farbe
Yellow to orange
Geruch (Odor)
Odorless
Säure-Base-Indikators(pH-Indikatoren)
4
Wasserlöslichkeit
1.6 mg/L (25 ºC)
Merck 
14,4221
BRN 
100781
Stabilität:
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
InChIKey
OVBPIULPVIDEAO-LBPRGKRZSA-N
CAS Datenbank
59-30-3(CAS DataBase Reference)
NIST chemische Informationen
Folic acid(59-30-3)
EPA chemische Informationen
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 33-62-68
S-Sätze: 24/25
WGK Germany  1
RTECS-Nr. LP5425000
8
TSCA  Yes
HS Code  29362900
Giftige Stoffe Daten 59-30-3(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Folsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R33:Gefahr kumulativer Wirkungen.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R68:Irreversibler Schaden möglich.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

orange to yellow crystalline powder

Occurrence

Synthetic

Verwenden

folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

Verwenden

Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

Verwenden

Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

Verwenden

A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Verwenden

hematopoietic vitamin

Definition

ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

Allgemeine Beschreibung

Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

Air & Water Reaktionen

Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

Reaktivität anzeigen

Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

Brandgefahr

Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

Sicherheitsprofil

Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

läuterung methode

If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

Folsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Folsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 590)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 115 55
Univar Solutions(China) Co., Ltd.
15902132654
86-21-61932700 Ivy.zhuang@univarsolutions.com CHINA 137 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19927 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21826 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3224 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1011 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58

59-30-3(Folsure)Verwandte Suche:


  • N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID
  • n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid
  • VITIMIN M
  • VITAMIN BC
  • Vitamin B11
  • VITAMIN M
  • ACIDUM FOLICUM
  • INCAFOLIC
  • FOLSAN
  • FOLSAURE
  • FOLIC ACID
  • FOLIC ACID HYDRATE
  • FOLACIN
  • CYTOFOL
  • l-pteroylglutamic acid
  • 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino
  • 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-
  • acfol(spain)
  • Acifolic
  • antianemiafactor
  • component of Mission prenatal
  • component of Plastulen-n
  • factoru
  • Folacid
  • folaemin(netherlands)
  • Folan
  • folasic(australia)
  • Folate
  • Folbal
  • Folcidin
  • Folcysteine
  • Foldine
  • foldine(france)
  • Folettes
  • Foliamin
  • folic
  • folicacid(vitaminb11)
  • Folicet
  • folico(italy)
  • folina(italy)
  • Folipac
  • Folsav
  • Foluite
  • Folvite
  • Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-
  • Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-
  • Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
  • Glutamic acid, pteroyl-, l-
  • glutamicacid,n-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amin
  • Kyselina listova
  • kyselinalistova
  • L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
  • l-glutamicacid,n-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)be
  • l-glutamicacid,n-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]be
  • Liver Lactobacillus, casei factor
  • liverlactobacilluscaseifactor
  • Millafol
  • Mission prenatal
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