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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Struktur
52853-40-4
CAS-Nr.
52853-40-4
Englisch Name:
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Synonyma:
6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide;2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide;Nsc253943;Methotrexate Impurity 15;Methotrexate Impurity 16;Methotrexate Impurity 17 HBr;6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR;2, 4-diaMino-6-(broMoMethyl)-pteridine HCL;6-Bromomethyl-pteridine-2,4-diamine hydrobromide;2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
CBNumber:
CB51010881
Summenformel:
C7H8Br2N6
Molgewicht:
335.99
MOL-Datei:
52853-40-4.mol
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Eigenschaften

Schmelzpunkt:
>195°C (dec.)
storage temp. 
-20°C Freezer
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
Light Brown to Brown
InChI
InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
InChIKey
KMQIBGKVZDBGAH-UHFFFAOYSA-N
SMILES
NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

Chemische Eigenschaften

Light Brown Solid

Verwenden

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Application

6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Natriumacetat Ethanol 1,3-Dihydroxyaceton Hydrogenbromid Diethylether L-Cystein Brom Essigsure Pyrimidintetrayltetraaminsulfat Bariumchlorid Triphenylphosphin N,N-Dimethylacetamid Holzkohle, aktiviert Bariumsulfat

Downstream Produkte

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1,5-bis(cyanomethyl) ester

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 156)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
 eric@witopchemical.com China 23556 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8615821988213
 info@longyupharma.com China 2531 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366
export01@shyrchem.com CHINA 1320 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58

52853-40-4()Verwandte Suche:

1-Brom-2-methoxyethan N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure 2,4-Diaminopteridin-6-ylmethanol Methotrexate
  • 2, 4-diaMino-6-(broMoMethyl)-pteridine HCL
  • 2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)
  • 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
  • 2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
  • 2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide
  • 6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)
  • Nsc253943
  • 6-Bromomethyl-pteridine-2,4-diamine hydrobromide
  • 2,4-PteridinediaMine, 6-(broMoMethyl)-, hydrobroMide (1:1)
  • 6-(Bromomethyl)-2,4-pteridinediamine hydrochloride
  • 6-(Bromomethyl)pteridine-2,4-diamine hydrobromide (1:1)
  • Methotrexate Impurity 15
  • 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, tech grade
  • Methotrexate Impurity 16
  • 6-Bromomethyl-pteridine-2,4-diamine hbrQ: What is 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the CAS Number of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the storage condition of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What are the applications of 6-Bromomethyl-pteridine-2,4-diamine hbr
  • 2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide
  • 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide
  • Methotrexate Impurity 17 HBr
  • 6-(bromomethyl)-2,4-Pteridinediamine hydrobromide (1:1)
  • 52853-40-4
  • C7H72N6HBr
  • C7H8Br2N6
  • BrHC7H7BrN6
  • C7H7BrN6BrH
  • Aromatics
  • Bases & Related Reagents
  • Inhibitors
  • Nucleotides
  • Aromatics Compounds
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