Nedaplatin

Nedaplatin Struktur
95734-82-0
CAS-Nr.
95734-82-0
Englisch Name:
Nedaplatin
Synonyma:
254-s;Aqupla;Nedaplait;NEDAPLATIN;NSC 375101D;Nedaplatin, >=99%;Nedaplatin USP/EP/BP;Nedaplatin (NSC 375101D);cis-diammine(glycolato)platinum(ii);(glycolato-o,o')diammineplatinum(ii)
CBNumber:
CB5127746
Summenformel:
C2H6N2O3Pt
Molgewicht:
301.17
MOL-Datei:
95734-82-0.mol

Nedaplatin Eigenschaften

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
Löslichkeit
H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
Aggregatzustand
Powder
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Nedaplatin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.

Verwenden

Nedaplatin is a platinum complex that has potent antineoplatic activity.

Pharmazeutische Anwendungen

Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin. The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular, ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect is myelosuppression.

Nedaplatin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nedaplatin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 213)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Wuhan Chemwish Technology Co., Ltd
027-67849912
sales@chemwish.com CHINA 10828 58
Jinan Honest Pharm Co., Ltd
+8615318812076
zpy8217@163.com China 286 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5739 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386
marketing1@neostarunited.com China 8349 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58

95734-82-0()Verwandte Suche:


  • (glycolato-o,o')diammineplatinum(ii)
  • cis-diammine(glycolato)platinum(ii)
  • NEDAPLATIN
  • 254-s
  • o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
  • Nedaplait
  • o(sup 2))- diammine(hydroxyacetato(2-)-o(sup 1 (sp-4-3)-platinu (glycolato-o,o')diammineplatinum(ii) 254-s cis-diammine(glycolato)platinum(ii) nedaplatin nsc 375101d
  • 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one
  • PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-, (SP-4-3)-
  • (SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum
  • Nedaplatin, >=99%
  • cis-Diammine(glycolato(2-)O,O')platinum
  • Cis-diammine-glycoloato-O,O'-platinum(II)
  • platinum(2+) azanide- hydroxyacetic acid(1:2:1)
  • cis-diamine-glycolate-O,O'-platinum(II)
  • Aqupla
  • NSC 375101D
  • Nedaplatin USP/EP/BP
  • Nedaplatin (NSC 375101D)
  • 95734-82-0
  • C2H4N2O3Pt
  • C2H8N2O3Pt
  • C2H2O3Pt2H3N
  • Inhibitors
  • Anticancer
  • Anticancer Platinum Agent
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