Paroxetine

Paroxetine Struktur
61869-08-7
CAS-Nr.
61869-08-7
Englisch Name:
Paroxetine
Synonyma:
PAXIL;PAROXETIN HCL;AROPAX;FG 7051;BRL 29060;AROPAX 20;Paloxitene;PAROXETINE;PARORETINE HCL;Paroxetine 99%
CBNumber:
CB5178021
Summenformel:
C19H20FNO3
Molgewicht:
329.37
MOL-Datei:
61869-08-7.mol

Paroxetine Eigenschaften

Schmelzpunkt:
114-116°C
Siedepunkt:
451.7±45.0 °C(Predicted)
Dichte
1.1844 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
pKa 9.51 (Uncertain)
CAS Datenbank
61869-08-7(CAS DataBase Reference)
NIST chemische Informationen
Paroxetine(61869-08-7)
EPA chemische Informationen
Paroxetine (61869-08-7)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
Giftige Stoffe Daten 61869-08-7(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Paroxetine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Paroxetine is a new highly selective serotonin reuptake inhibitor, mechanistically similar to fluoxetine, fluvoxamine and sertraline, introduced for the treatment of all types of depressive illnesses including depression associated with anxiety. It is reportedly non-sedating and non-stimulatory and compared to fluoxetine has a shorter duration of action (half-life of 24 hours versus 2 to 3 days). Paroxetine is also being investigated as a treatment for obesity, alcoholism and obsessive-compulsive disorders.

Chemische Eigenschaften

White Solid

Verwenden

A istopically labelled selective serotonin reuptake inhibitor. Used as an antidepressant

Biologische Funktion

Paroxetine (Paxil) has an elimination half-life of 21 hours and is also highly bound to plasma proteins, so it requires special attention when administered with drugs such as warfarin. Paroxetine is a potent inhibitor of the cytochrome P450 2D6 isoenzyme and can raise the plasma levels of drugs metabolized via this route. Of particular concern are drugs with a narrow therapeutic index, such as TCAs and the type 1C antiarrhythmics flecainide, propafenone, and encainide. Additionally, paroxetine itself is metabolized by this enzyme and inhibits its own metabolism, leading to nonlinear kinetics. Weight gain is higher with paroxetine than with the other SSRIs, and it tends to be more sedating, presumably because of its potential anticholinergic effects. Additionally, patients have had difficulty with abrupt discontinuation with this agent, reporting a flulike syndrome; this symptom can be avoided by tapering the medication.

Allgemeine Beschreibung

In the structure of paroxetine (Paxil), an amino group, protonatedin vivo could H-bond with the–CH2–O– unshared electrons.A β-arylamine–like structure with an extra aryl groupresults. The compound is a very highly selective SERT. Asexpected, it is an effective antidepressant and anxiolytic.

Clinical Use

In vitro binding studies suggest that paroxetine is a more selective and potent inhibitor of 5-HT reuptake than fluoxetine. The drug essentially has no effect on NE or dopamine reuptake, nor does it show affinity for other neuroreceptors. Its onset of action is 1 to 4 weeks.

Paroxetine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Paroxetine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 232)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Boyuan Import & Export Co., LTD
+86-15175982296 15175982296;
Mike@whby-chem.com China 981 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12452 58
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+86-18031140164 +86-19933155420
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Wuhan Xinhao Biotechnology Co., Ltd
+86-18120578002 +86-18120578002
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Sigma Audley
+86-18336680971 +86-18126314766
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hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
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+86-13734021967 +8613734021967
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+86-0371-86658258
sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58

61869-08-7()Verwandte Suche:


  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3s,4r)-piperidin
  • 3α-(1,3-Benzodioxole-5-yloxymethyl)-4β-(4-fluorophenyl)piperidine
  • 3α-[(1,3-Benzodioxol-5-yl)oxymethyl]-4β-(4-fluorophenyl)piperidine
  • (3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)piperidine
  • Paroxetine HCl anhydrous API
  • (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
  • Paloxitene
  • Piperidine,3-[(1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)-, (3S,4R)-
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidin(3s-trans)
  • BRL 29060
  • AROPAX
  • AROPAX 20
  • FG 7051
  • PAROXETIENE BASE
  • PAROXETINE
  • (-)-TRANS-4R-(4'-FLUOROPHENYL)-3S-[(3',4'-METHYLENEDIOXY-PHENOXY) METHYL]PIPERIDINE
  • rac trans-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride
  • (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine
  • Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)- (9CI)
  • Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S-trans)-
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
  • (-)-trans-4R-(4'-Fluorophenyl)-3S-((3',4'-methylenedioxyphenoxy)methyl)piperidine
  • PARORETINE HCL
  • ParoxetineHclBase
  • (3S,4R)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FFLUOROPHENYL)PIPERIDINE
  • (-)-trans-4-(4-Fluorophenyl)-3-hydroxy methyl-N-me
  • (3R)-3α-[3,4-(Methylenebisoxy)phenoxymethyl]-4β-(4-fluorophenyl)piperidine
  • Paroxetine-002-SR
  • Paroxetine-002-3S4R
  • 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine hydrate hydrochloride
  • Paroxetine hydrochloride (anhydrous) CRS
  • Paroxetine for system suitability CRS
  • trans-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
  • Paroxetine USP/EP/BP
  • Paroxetine 99%
  • PAXIL
  • PAROXETIN HCL
  • Paroxetine EP Standard
  • (-)-Paroxetine
  • 61869-08-7
  • C19H17D4ClFNO3
  • C19H20FNO3
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
  • API's
  • Paroxetine
  • Fluorobenzene
  • APIs
  • 61869-08-7
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