2,3-Dichlorbenzoesure

2,3-Dichlorobenzoic acid Struktur
50-45-3
CAS-Nr.
50-45-3
Bezeichnung:
2,3-Dichlorbenzoesure
Englisch Name:
2,3-Dichlorobenzoic acid
Synonyma:
2,3-Dichlorobenzoic;2,3-Dichlorbenzoesure;2,3-dichloro-benzoicaci;2,3-DICHLOROBENZOIC ACID pure;2,3-Dichlorobe;TIMTEC-BB SBB003641;RARECHEM AL BO 0323;2,3-dichlorobenzoate;3-Dichlorobenzoic acid;2,3-Dichorobenzoic acid
CBNumber:
CB5227477
Summenformel:
C7H4Cl2O2
Molgewicht:
191.01
MOL-Datei:
50-45-3.mol

2,3-Dichlorbenzoesure Eigenschaften

Schmelzpunkt:
168-170 °C (lit.)
Siedepunkt:
273.68°C (rough estimate)
Dichte
1.4410 (rough estimate)
Brechungsindex
1.4590 (estimate)
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
2.53±0.25(Predicted)
Farbe
White to Off-White
Wasserlöslichkeit
slightly soluble
BRN 
1946217
InChI
InChI=1S/C7H4Cl2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)
InChIKey
QAOJBHRZQQDFHA-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(Cl)=C1Cl
CAS Datenbank
50-45-3(CAS DataBase Reference)
EPA chemische Informationen
2,3-Dichlorobenzoic acid (50-45-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-37/39-36-24/25
WGK Germany  2
RTECS-Nr. DG6475000
HazardClass  IRRITANT
HS Code  29163990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2,3-Dichlorbenzoesure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

white to light yellow crystal powder

Verwenden

2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug Lamotrigine (L173250) and other pharmaceuticals for the treatment of central nervous system (CNS) disorders and disease.

Allgemeine Beschreibung

2,3-Dichlorobenzoic acid is an intermediate metabolite of polychlorinated biphenyls (PCBs).

Synthese

2,3-Dichlorobenzoic acid was prepared from 2,3-dichloroaniline by diazotization and Myerwine reaction to 2,3-dichlorobenzaldehyde, and then oxidized by potassium permanganate, with an overall yield of 45%.
Another synthesis of 2,3-dichlorobenzoic acid:
Step (a) A solution of 2,3-dichloroiodobenzene in sodium dried ether was added dropwise to magnesium turnings and a crystal of iodine with warming so as to form a Grignard reagent.
Step (b) The mixture of Step (a) was stirred and refluxed then cooled and transferred dropwise, under nitrogen, into a stirred mixture of sodium dried ether containing solid carbon dioxide.
Step (c) The mixture of Step (b) was stirred for 2 hours, left overnight to warm to room temperature, then treated with ice and aqueous hydrochloric acid, and the product extracted with ether. The combined ether extracts were washed with water then repeatedly extracted with an aqueous sodium hydroxide. These basic solutions were combined, stirred with activated charcoal for 10 minutes, filtered and the cooled filtrate was acidified with concentrated hydrochloric acid at lO.degree. C.
Step (d) The resultant solid was filtered off, washed with water (2.times.20 mis) and dried in vacuo. Yield 77.6%.

läuterung methode

Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.] Crystallise the acid from H2O, aqueous EtOH, or 30% aqueous AcOH and several times from *C6H6, then dry it in vacuo at 40o overnight. The methyl ester has m 35-39o . [Hope & Riley J Chem Soc 123 2478 1923, Lock Monatsh Chem 90 687 1959, Shorter & Mather J Chem Soc 4744 1961, Beilstein 9 II 228, 9 IV 998.]

2,3-Dichlorbenzoesure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2,3-Dichlorbenzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 503)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Speranza Chemical Co., Ltd.
+86-86-075521030354 +8618688942810
sophieliu@speranzachem.com China 723 55
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
daisy@crovellbio.com China 5966 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 14764 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9354 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58

50-45-3(2,3-Dichlorbenzoesure)Verwandte Suche:


  • Lamotrigine Related Compound B (USP)
  • 2,3Dichlorobenzoic acid (Lamotrigine Related Compound B)
  • RARECHEM AL BO 0323
  • TIMTEC-BB SBB003641
  • 2,3-DICHLOROBENZOIC ACID
  • 2,3-DICHLOROBENZOIC ACID PESTANAL, 250 M
  • 2,3-Dichlorobenzoicacid,98%
  • Benzoic acid, 2,3-dichloro-
  • 3-Dichlorobenzoic acid
  • Lamotrigine Related Compound B (20 mg) (2,3-dichlorobenzoic acid)
  • 2,3-Dichlorobe
  • Lamotrigine Impurity E (2,3-Dichlorobenzoic Acid)
  • 2,3-Dichorobenzoic acid
  • LaMotrigine Related CoMpound B
  • Lamotrigine impurity E (PhEur)
  • Lamotrigine EP impurity E
  • 2,3-dichlorobenzoate
  • Lamotrigine impurity E CRS
  • 2,3-DichlorobenzoicAcid>
  • Lamotrigine EP Impurity E (2,3-Dichlorobenzoic Acid)
  • Lamotrigine Impurity 4 (Lamotrigine EP Impurity E)
  • Lamotrigine EP Impurity E/ Lamotrigine Related Compound B
  • Lamotrigine Impurity EQ: What is Lamotrigine Impurity E Q: What is the CAS Number of Lamotrigine Impurity E Q: What is the storage condition of Lamotrigine Impurity E
  • Lamotrigine Related Compound B (2,3-dichlorobenzoic acid) (1356778)
  • 2,3-dichloro-benzoicaci
  • 2,3-Dichlorobenzoic
  • 2,3-Dichlorbenzoesure
  • 2,3-DICHLOROBENZOIC ACID pure
  • Lamotrigine USP Related Compound B
  • Lamotrigine EP Impurity E (Lamotrigine USP Related Compound B)
  • Lamotrigine EP Impurity-E / Lamotrigine Relaed Compound-B
  • 50-45-3
  • 50-46-3
  • 50-43-3
  • HOOCC6H3Cl2
  • C7H3Cl2O2
  • Building Blocks
  • C7
  • Carboxylic Acids
  • Carbonyl Compounds
  • Organic Building Blocks
  • Alpha sort
  • D
  • DAlphabetic
  • DIA - DIC
  • Pesticides&Metabolites
  • C7
  • Carbonyl Compounds
  • Carboxylic Acids
  • intermediate
  • acid
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzoic acid
  • Organic acids
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