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Acotiamide hydrochloride trihydrate Produkt Beschreibung

Acotiamide hydrochloride trihydrate Struktur
773092-05-0
CAS-Nr.
773092-05-0
Englisch Name:
Acotiamide hydrochloride trihydrate
Synonyma:
Ym-443;Acotiae;Acotiamide HCl;Unii-nmw7447A9a;Acofide trihydrate;Acotiamide trihydrate;Acotiamide HCl Hydrate;Acotiamide hydrochlorid;Acotiamide HCl Trihydrate;Acotiamide hydrochloride hydrate
CBNumber:
CB52493115
Summenformel:
C21H31ClN4O5S
Molgewicht:
487.013
MOL-Datei:
773092-05-0.mol

Acotiamide hydrochloride trihydrate Eigenschaften

Sicherheit

Acotiamide hydrochloride trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.

Originator

Zeria Pharmaceutical (Japan)

Trademarks

Acofide

Acotiamide hydrochloride trihydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Acotiamide hydrochloride trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 115)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Anhui Dexinjia Biopharm Co., Ltd
86-531-82375818,82375892
86-531-82375893 alice@jndxj.com CHINA 129 58
Shandong ruiyue Biological Technology Co.,Ltd.
008615066100122(Lily wechat);008618953188003(Fiona wechat);008618805314509(wechat)
053188581623 513075341@qq.com;1021501167@qq.com;1456922171@qq.com CHINA 59 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1018 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58

  • Acotiae
  • 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3)
  • Acofide trihydrate
  • N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino]
  • Acotiamide HCl Hydrate
  • N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate
  • Acotiamide HCl Trihydrate
  • N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro
  • N-[2-[DI(PROPAN-2-YL)AMINO]ETHYL]-2-[(2-HYDROXY-4,5-DIMETHOXYBENZOYL)AMINO]-1,3-THIAZOLE-4-CARBOXAMIDE
  • Acotiamide hydrochlorid
  • Acotiamide trihydrate
  • AcotiaMide hydrochloride hydrate CAS 773092-05-0
  • Hot sale top quality Acotiamide hydrochloride hydrate with factory price
  • High Quality Acotiamide hydrochloride hydrate
  • Acotiamide hydrochloride hydrate Acotiamide HCl 773092-05-0
  • Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0
  • Acotiamide HCl
  • Acotiamide hydrochloride hydrate
  • N-(2-(Diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxyamide monohydrochloride trihydrate
  • Unii-nmw7447A9a
  • Ym-443
  • AcotiaMide hydrochloride trihydrate
  • Acotamine hydrochloride trihydrate
  • N-[2-(Diisopropylamino)ethyl]-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide Hydrochloride Trihydrate
  • 773092-05-0
  • C21H30N4O5SHCl3H2O
  • C21H37ClN4O8S
  • C21H31ClN4O5S
  • Inhibitors
  • API
  • -
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