3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
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- CAS-Nr.
- 1232410-49-9
- Englisch Name:
- 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
- Synonyma:
- VE-821;AVE821;CS-634;VE821;VE 821;ATR Inhibitor IV;VE-821;VE821;VE 821;VE-821 VE821 ATR Inhibitor IV;3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide;3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide;3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide
- CBNumber:
- CB52534719
- Summenformel:
- C18H16N4O3S
- Molgewicht:
- 368.41
- MOL-Datei:
- 1232410-49-9.mol
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3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Eigenschaften
- Schmelzpunkt:
- 247-249°C
- Siedepunkt:
- 568.4±50.0 °C(Predicted)
- Dichte
- 1.394
- storage temp.
- -20°C
- Löslichkeit
- Soluble in DMSO (40 mg/ml)
- Aggregatzustand
- powder
- pka
- 9.97±0.70(Predicted)
- Farbe
- white to beige
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC
50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.
Chemische Eigenschaften
Bright Yellow Solid
Verwenden
VE 821 is a potent and selective inhibitor of DNA damage response kinase, ATR. VE 821 functions to disrupt DNA damage repair system of tumor cells, limiting their abilities for further growth.
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 134)Lieferanten
- VE-821;VE821;VE 821
- 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
- 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-
- 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide VE-821
- VE-821 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
- 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide
- VE821;VE 821
- CS-634
- 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
- AVE821
- ATR Inhibitor IV
- 3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide
- 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide USP/EP/BP
- VE-821
- VE-821 VE821 ATR Inhibitor IV
- VE 821,ATM and RAD3 related,ATM/ATR,Inhibitor,Ataxia telangiectasia mutated,VE821,VE-821,inhibit
- 1232410-49-9
- Inhibitors
- API
