5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
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- CAS-Nr.
- 881674-56-2
- Englisch Name:
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Synonyma:
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
- CBNumber:
- CB52638918
- Summenformel:
- C11H8FNO
- Molgewicht:
- 189.19
- MOL-Datei:
- 881674-56-2.mol
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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Eigenschaften
- Schmelzpunkt:
- 133 °C
- Siedepunkt:
- 370.6±32.0 °C(Predicted)
- Dichte
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 14.77±0.50(Predicted)
- Farbe
- Light Brown to Brown
- Stabilität:
- Hygroscopic
- InChI
- InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
- InChIKey
- MQULPEUCGKEHEG-UHFFFAOYSA-N
- SMILES
- N1C(C2=CC=CC=C2F)=CC(C=O)=C1
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.
Chemische Eigenschaften
Light orange to Yellow to Green powder to crystal.
Verwenden
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
synthetische
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Definition
The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.
Hazard
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 469)Lieferanten
881674-56-2()Verwandte Suche:
- 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-
- 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
- TAK-438( Vonoprazan fumarate) intermediate 3
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...
- 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-
- TAK438 Impurity 54
- 1-[(2S) -2-pyrrolidinecarbonyl] -pyrrolidine
- TAK438 Intermediate
- Vonoprazan-1
- 5-(2-Fluorophenyl)pyrrole-3-carbaldehyde
- Vonoprazan-023
- 5-(2-FL
- e-3-carbaL
- )-1H-pyrroL
- 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehy
- 5 - (2-fluorophenyl) - 1h-pyrrole-3-formaldehyde
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde
- 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
- VONOPRAZAN IST-1
- Vonorazan
- 5-(2-Fluorophenyl)-1H-pyrrol-3-carbaldehyde
- Vonolazan impurity 1
- TAK438 Impurity 54 CRS
- 881674-56-2
- 881647-56-2
- Vonoprazan
- Pharmaceutical Intermediates
- 881674-56-2
