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Chlorambucil Produkt Beschreibung

Chlorambucil Struktur
305-03-3
CAS-Nr.
305-03-3
Bezeichnung:
Chlorambucil
Englisch Name:
Chlorambucil
Synonyma:
cb1348;CB 1348;Cb l348;Ecloril;Elcoril;elcorin;nsc3088;Leukeran;Leukoran;NSC 3088
CBNumber:
CB5270716
Summenformel:
C14H19Cl2NO2
Molgewicht:
304.21216
MOL-Datei:
305-03-3.mol

Chlorambucil Eigenschaften

Schmelzpunkt:
65-70 °C
Dichte
1.2486 (rough estimate)
Brechungsindex
1.6070 (estimate)
storage temp. 
2-8°C
Löslichkeit
Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
Aggregatzustand
neat
pka
pKa ~1.3(H2O) (Uncertain)
Wasserlöslichkeit
<0.01 g/100 mL at 22 ºC
maximale Wellenlänge (λmax)
588nm(DMSO aq.)(lit.)
Merck 
14,2073
BRN 
999011
Stabilität:
Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N
CAS Datenbank
305-03-3(CAS DataBase Reference)
NIST chemische Informationen
Chlorambucil(305-03-3)
EPA chemische Informationen
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (305-03-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 45-25-36/37/38
S-Sätze: 53-26-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. ES7525000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29224999
Giftige Stoffe Daten 305-03-3(Hazardous Substances Data)
Toxizität LD50 i.p. in rats: 58.2 mmole/kg (Ross)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Chlorambucil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

beige powder

Chemische Eigenschaften

Chlorambucil is a crystalline solid

Verwenden

antineoplastic, alkylating agent

Verwenden

Chlorambucil is a alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease.

Verwenden

Chlorambucil-d8 is the isotope labelled analogue of Chlorambucil (C324050), an alkylating agent that is used in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Ho dgkin's lymphoma (NHL) and Hodgkin's disease.

Verwenden

tranquilization aid

Definition

ChEBI: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Indications

Chlorambucil (Leukeran) is an aromatic nitrogen mustard that is intermediate in chemical reactivity between mechlorethamine and melphalan. Its mechanisms of action and range of antitumor activity are similar to theirs. It is well absorbed orally, but detailed information concerning its metabolic fate in humans is lacking.
Chlorambucil is used primarily as daily palliative therapy for chronic lymphocytic leukemia, Waldenstr?om’s macroglobulinemia, myeloma, and other lymphomas.
Bone marrow toxicity is the major side effect of chlorambucil. Nausea is uncommon or mild, and hair loss does not occur. Chlorambucil shares the immunosuppressive, teratogenic, and carcinogenic properties of the nitrogen mustards.

Trademarks

Leukeran (GlaxoSmithKline.

Allgemeine Beschreibung

White to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.

Allgemeine Beschreibung

Chlorambucil is available as 2-mg tablets for oral administrationin the treatment of Hodgkin’s lymphoma, andchronic lymphocytic leukemia in combination with prednisoneand as a single agent. The mechanisms of resistanceare the same as those seen for other agents of the class suchas mechlorethamine. The agent is well absorbed (75%) uponoral administration and highly protein bound. Metabolism ismediated by CYP and occurs extensively to give severalmetabolites, including the active phenylacetic acid–nitrogenmustard. The drug is eliminated via the kidneys with a terminalelimination half-life of 1.5 hours. Adverse effects includedose-limiting myelosuppression, which are seen asboth leucopenia and thrombocytopenia. Nausea and vomitingoccur less often than for mechlorethamine. Additionaladverse effects include hyperuricemia, azoospermia, amenorrhea,seizures, pulmonary fibrosis, and skin rash.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Chloroambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds .

Brandgefahr

Literature sources indicate that Chloroambucil is nonflammable.

Sicherheitsprofil

Confirmed carcinogen producing leukemia. Experimental carcinogenic and neoplastigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: convulsions, cough, dyspnea, and interstitial fibrosis. Human reproductive effects by ingestion and possibly other routes: changes in spermatogenesis, menstrual cycle changes or disorders, and teratogenic effects of the fetal urogenital system. Experimental teratogenic and reproductive effects. Human mutation data reported. An anti-neoplastic agent. When heated to decomposition it emits very toxic fumes of Cland NOx.

mögliche Exposition

Chlorambucil, an anticancer drug, is a derivative of nitrogen mustard. This drug is primarily used as an antineoplastic agent for treating lymphocytic leukemia; malignant lymphomas; follicular lymphoma; and Hodgkin’s disease. The treatments are not curative but do produce some marked remissions. Chlorambucil has also been tested for treatment of chronic hepatitis, rheumatoid arthritis; and as an insect chemosterilant. All of the chemical used in this country is imported from the United Kingdom. Work exposure in the United States would be limited to workers formulating the tablets, or to those patients receiving the drug.

Veterinary Drugs and Treatments

Chlorambucil may be useful in a variety of neoplastic diseases, including lymphocytic leukemia, multiple myeloma, polycythemia vera, macroglobulinemia, and ovarian adenocarcinoma. It may also be useful as adjunctive therapy for some immune-mediated conditions (e.g., glomerulonephritis, inflammatory bowel disease, nonerosive arthritis, or immune-mediated skin disease). It has found favor as a routine treatment for feline pemphigus foliaceous and severe feline eosinophilic granuloma complex due to the drug’s relative lack of toxicity in cats and efficacy.

Carcinogenicity

Chlorambucil is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

läuterung methode

Chlorambucil is recrystallised from pet ether (flat needles) and has a solubility at 20o of 66% in EtOH, 40% in CHCl3, 50% in Me2CO but is insoluble in H2O [Everett et al. J Chem Soc 2386 1953]. [Beilstein 14 IV 1715.] CARCINOGEN.

Inkompatibilitäten

Moisture. Chlorambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may beharmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properlylabel and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Permanganate oxidation, high temperature incineration with scrubbing equipment, or microwave plasma treatment.

Verordnung (Regulations)

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 10 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of chlorambucil = U035. Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
Chlorambucil is a prescription drug subject to labeling and other requirements.

Chlorambucil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlorambucil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 153)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23967 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58

305-03-3(Chlorambucil)Verwandte Suche:


  • CHLORAMBUCIL
  • chloroambucil
  • 4(p-bis(beta-chloroethyl)aminophenyl)butyricacid
  • 4-[Bis(2-chioroethyl)amino]benzenebutanoicacid
  • Ambochlorin
  • Amboclorin
  • Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
  • Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
  • butanoicacid,4-[3-[bis(2-chloroethyl)amino]phenyl]-
  • Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
  • butyricacid,4-(p-(bis(2-chloroethyl)amino)phenyl)
  • CB 1348
  • Cb l348
  • cb1348
  • Chloraminophen
  • Chloraminophene
  • Chlorbutin
  • Chlorbutine
  • Chlorobutin
  • Chlorobutine
  • Ecloril
  • Elcoril
  • elcorin
  • gamma-(p-bis(2-chloroethyl)aminophenyl)butyricacid
  • gamma-(p-di(2-chloroethyl)aminophenyl)butyricacid
  • gamma-[p-Di(2-chloroethyl)aminophenyl]butyric acid
  • Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna
  • kyselina4-(n,n-bis-(2-chlorethyl)-p-aminofenyl)maselna
  • Leukeran
  • Leukeran tablets
  • Leukersan
  • Leukoran
  • Linfolizin
  • Linfolysin
  • lympholysin
  • N,N-Di-2-chloroethyl-gamma-p-aminophenylbutyric acid
  • n,n-di-2-chloroethyl-gamma-p-aminophenylbutyricacid
  • n,n-di-2-chloroethyl-gamma-para-aminophenylbutyricacid
  • NCI-C03485
  • ncl-co3485
  • NSC 3088
  • nsc3088
  • nsc-3088
  • p-(n,n-di-2-chlorethylaminophenylbutyricacid
  • p-(N,N-Di-2-chloroethyl)aminophenyl butyric acid
  • 4-(p-N,N-Di-(beta-chloroethyl)aminophenyl)butyric acid
  • CHLOCAMBUCIL
  • Chloroambucil=Chloroaminophene=Amboclorin=Leukeran
  • 4-((P-BIS-(B-CHLOROETHYL)AMINO)PHENYL)BUTYRIC ACID
  • 4-(4-[bis(2-chloroethyl)amino]phenyl)butyric acid
  • CHLORAMBUCIL,USP
  • BUTYRICACID,4-(PARA-BIS(2-CHLOROETHYL)AMINOPHENYL)-
  • Benzenebutanoic acid, 4-[bis92-chloroethyl)amino]-
  • 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid
  • Chlorambucil,4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid
  • Chlorambucil (125 mg) (FOR U.S. SALE ONLY)
  • Chlorambucil (125 mg) (International Restricted Sales Item)
  • ChloraMbucil-d8
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