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7-Ethyl-10-hydroxycamptothecin Produkt Beschreibung

7-Ethyl-10-hydroxycamptothecin Struktur
86639-52-3
CAS-Nr.
86639-52-3
Englisch Name:
7-Ethyl-10-hydroxycamptothecin
Synonyma:
SN38;EHCPT;NK 012;SN-38:SN38;10-dihydroxy-;SN-38(NK-012); SN 38 Lactone;Irinotecan USP RC B;Irinotecan Impurity 15;7-ETHYL-10-HYDROXY-CPT
CBNumber:
CB5320664
Summenformel:
C22H20N2O5
Molgewicht:
392.4
MOL-Datei:
86639-52-3.mol

7-Ethyl-10-hydroxycamptothecin Eigenschaften

Schmelzpunkt:
217 °C
Siedepunkt:
810.3±65.0 °C(Predicted)
Dichte
1.51±0.1 g/cm3(Predicted)
Brechungsindex
21.5 ° (C=0.2, THF)
storage temp. 
2-8°C
Löslichkeit
DMSO: soluble1mg/mL
Aggregatzustand
powder
pka
9.13±0.40(Predicted)
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS Datenbank
86639-52-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25
S-Sätze: 45
RIDADR  2811
WGK Germany  3
RTECS-Nr. UQ0491000
HazardClass  6.1
PackingGroup 
HS Code  29399990
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P403+P233 An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

7-Ethyl-10-hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Light-Yellow Solid

Verwenden

A metabolite of Irinotecan, a DNA topoisomerase inhibitor

Definition

ChEBI: A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substitu nts at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.

Biologische Aktivität

Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

7-Ethyl-10-hydroxycamptothecin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


7-Ethyl-10-hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 480)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Unibest Industrial Co.,Ltd.
+86-0574-27855661
+86 574 2785 6789 info@unibestcn.com China 32 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

86639-52-3()Verwandte Suche:


  • 7-10-hydroxycamptothecin
  • (4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • EHCPT
  • 7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38
  • 10-Hydroxycamptothecin acetate salt ,99%
  • Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
  • SN 38(7-Ethyl-10-hydroxycaMptothecin)
  • CaMptothecin, 7-ethyl-10-hydroxy (SN-38)
  • 7-Ethyl-10-hydroxy-20(S)-caMptothecin
  • (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 7-ETHYL-10-HYDRO(20)S-CAMPTOTHECIN
  • (S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Irinotecan Related CoMpound B
  • 7-Ethyl-10-Hydroxy Campothecin
  • 7-Ethyl-10-hydroxycamptothecin (TECANS)
  • 7-ethyl-10-hydrol-Camptothecin
  • 7-ETHYL-10-HYDROXYCAMPTTHECIN(SN38)
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
  • 7-Ethyl-10-hydroxycamptothecin 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxycamptothecin
  • 7-Ethyl-10-hydroxycamptothecin, >=99%
  • Crude Glycyrrhetinic Acid
  • SN-38:SN38
  • Irinotecan USP RC B
  • (4S)-4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3,4
  • 6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
  • Irinotecan Impurity 15
  • NK 012
  • 7-etyl-10-hydroxycaMptothecin
  • 7,11-Diethyl-10- hydroxy-caMptothecin
  • Ethyl-10-hydroxycaMptoth
  • 11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • CaMptothecin 7-Ethyl-10-Hydroxy IMpurity
  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN
  • 7-ETHYL-10-HYDROXYCAMPTOTHECINE
  • 7-ETHYL-10-HYDROXY-CPT
  • CAMPTOTHECIN, 7-ETHYL-10-HYDROXY
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • SN38
  • 10-dihydroxy-
  • 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
  • 7-ethyl-10-hydroxy-captotheci
  • 7-Ethyl-10-hydroxycamptothecin(SN-38)
  • SN 38 Lactone
  • 7-Ethyl-10-hydroxycamptothecin 86639-52-3
  • Irinotecan EP Impurity E
  • SN-38(NK-012)
  • (S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY E)
  • IRINOTECAN EP IMPURITY E ((S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN)
  • (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²
  • (S)-4,11-diethyl-4,9-dihydroxy-1H-benzo[f]pyrano[4',3':4,5]pyrido[2,1-a]isoindole-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxy campthothecin
  • 7-ethyl-10-hydroxycamptothecin 80-98%
  • 7-Ethyl-10-hydroxycamptothecin>
  • 7-Ethyl-10-hydroxycamptothecin USP/EP/BP
  • SN-38 (Synonyms: NK012)
  • Irinotecan EP Impurity E/ Irinotecan Related Compound B (7-Ethyl-10-Hydroxy Camptothecin/ 11-Ethyl-9-Hydroxy Camptothecin)
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