7-Ethyl-10-hydroxycamptothecin
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- CAS-Nr.
- 86639-52-3
- Englisch Name:
- 7-Ethyl-10-hydroxycamptothecin
- Synonyma:
- SN38;7-ETHYL-10-HYDROXYCAMPTOTHECINE;Irinotecan Related CoMpound B;(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione;(S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Irinotecan EP Impurity E/ Irinotecan Related Compound B (7-Ethyl-10-Hydroxy Camptothecin/ 11-Ethyl-9-Hydroxy Camptothecin);EHCPT;NK 012;SN-38:SN38;2H5]-SN-38
- CBNumber:
- CB5320664
- Summenformel:
- C22H20N2O5
- Molgewicht:
- 392.4
- MOL-Datei:
- 86639-52-3.mol
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7-Ethyl-10-hydroxycamptothecin Eigenschaften
- Schmelzpunkt:
- 217 °C
- Siedepunkt:
- 810.3±65.0 °C(Predicted)
- Dichte
- 1.51±0.1 g/cm3(Predicted)
- Brechungsindex
- 21.5 ° (C=0.2, THF)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble1mg/mL
- Aggregatzustand
- powder
- pka
- 9.13±0.40(Predicted)
- Farbe
- Off-white
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- FJHBVJOVLFPMQE-QFIPXVFZSA-N
- CAS Datenbank
- 86639-52-3(CAS DataBase Reference)
7-Ethyl-10-hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light-Yellow Solid
Verwenden
7-ethyl-10-hydroxycamptothecin (SN 38) is a metabolite of Irinotecan, a DNA topoisomerase inhibitor. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.
Definition
ChEBI: SN-38 (7-Ethyl-10-hydroxycamptothecin) is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an apoptosis inducer, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a drug metabolite and an antineoplastic agent. It is a pyranoindolizinoquinoline, a delta-lactone, a tertiary alcohol and a member of phenols.
Biologische Aktivität
Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
7-Ethyl-10-hydroxycamptothecin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-Ethyl-10-hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 618)Lieferanten
86639-52-3()Verwandte Suche:
- 7-10-hydroxycamptothecin
- (4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- EHCPT
- 7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38
- 10-Hydroxycamptothecin acetate salt ,99%
- Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
- SN 38(7-Ethyl-10-hydroxycaMptothecin)
- CaMptothecin, 7-ethyl-10-hydroxy (SN-38)
- 7-Ethyl-10-hydroxy-20(S)-caMptothecin
- (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 7-ETHYL-10-HYDRO(20)S-CAMPTOTHECIN
- 7-Ethyl-10-Hydroxy Campothecin
- 7-Ethyl-10-hydroxycamptothecin (TECANS)
- 7-ethyl-10-hydrol-Camptothecin
- 7-ETHYL-10-HYDROXYCAMPTTHECIN(SN38)
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
- 7-Ethyl-10-hydroxycamptothecin
4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-7-Ethyl-10-hydroxycamptothecin
- 7-Ethyl-10-hydroxycamptothecin, >=99%
- Crude Glycyrrhetinic Acid
- SN-38:SN38
- NK 012
- 7-etyl-10-hydroxycaMptothecin
- 7,11-Diethyl-10-
hydroxy-caMptothecin
- Ethyl-10-hydroxycaMptoth
- 11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- CaMptothecin 7-Ethyl-10-Hydroxy IMpurity
- 7-ETHYL-10-HYDROXYCAMPTOTHECIN
- 7-ETHYL-10-HYDROXY-CPT
- CAMPTOTHECIN, 7-ETHYL-10-HYDROXY
- 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-dihydroxy-
- 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
- 7-ethyl-10-hydroxy-captotheci
- 7-Ethyl-10-hydroxycamptothecin(SN-38)
- SN 38 Lactone
- Irinotecan USP RC B
- (4S)-4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3,4
- 6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
- Irinotecan Impurity 15
- 7-Ethyl-10-hydroxycamptothecin 86639-52-3
- Irinotecan EP Impurity E
- SN-38(NK-012)
- (S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY E)
- IRINOTECAN EP IMPURITY E ((S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN)
- (S)-4,11-diethyl-4,9-dihydroxy-1H-benzo[f]pyrano[4',3':4,5]pyrido[2,1-a]isoindole-3,14(4H,12H)-dione
- (S)-7-Ethyl-10-hydroxy campthothecin
- 7-ethyl-10-hydroxycamptothecin 80-98%
- 7-Ethyl-10-hydroxycamptothecin>
- 7-Ethyl-10-hydroxycamptothecin USP/EP/BP
- SN-38 （Synonyms: NK012）
- 7-Ethyl-1-hydroxycamptothecin
- 7-Ethyl-10-HydroxycamptothecinQ: What is
7-Ethyl-10-Hydroxycamptothecin Q: What is the CAS Number of
7-Ethyl-10-Hydroxycamptothecin Q: What is the storage condition of
7-Ethyl-10-Hydroxycamptothecin Q: What are the applications of
7-Ethyl-10-Hydroxycamptothecin
- 7-Ethyl-10-hydroxy-20(S)-campthothecin
- Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b] (1347631)
- Irinotecan EP Impurity E/ Irinotecan Related Compound B (7-Ethyl-10-Hydroxy Camptothecin/ 11-Ethyl-9-Hydroxy Camptothecin)
- SN38
