Magnesiumdistearat

Magnesium stearate  Struktur
557-04-0
CAS-Nr.
557-04-0
Bezeichnung:
Magnesiumdistearat
Englisch Name:
Magnesium stearate
Synonyma:
MAGNESIUM OCTADECANOATE;stearatedemagnesium;Magnesium Stearate Bp;C4d-A;Dolomol;Anti-C4d-A;硬脂酸镁生产厂家价格;petracmg20nf;nesium stearate;MAGENSIUM STEARATE
CBNumber:
CB5330900
Summenformel:
C36H70MgO4
Molgewicht:
591.24
MOL-Datei:
557-04-0.mol

Magnesiumdistearat Eigenschaften

Schmelzpunkt:
200 °C (lit.)
Dichte
1.028g/cm3
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
alcohol: insoluble
Aggregatzustand
Fine Powder
Farbe
White
PH
7 (H2O) (slurry)
Geruch (Odor)
wh. soft oily powd., tasteless, odorless
Wasserlöslichkeit
Insoluble
Merck 
14,5690
BRN 
3919702
Expositionsgrenzwerte
ACGIH: TWA 10 mg/m3; TWA 3 mg/m3
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
DRJIJXNWSSRTTE-UHFFFAOYSA-M
LogP
8.216 (est)
CAS Datenbank
557-04-0(CAS DataBase Reference)
EPA chemische Informationen
Magnesium stearate (557-04-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-37/39
WGK Germany  -
RTECS-Nr. WI4390000
TSCA  Yes
HS Code  29157030
Giftige Stoffe Daten 557-04-0(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: > 2000 mg/kg
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit

Magnesiumdistearat Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

WEISSES PULVER.

PHYSIKALISCHE GEFAHREN

Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich. Die trockene Substanz kann durch Verwirbeln, Druckluft, Fließen usw. elektrostatisch aufgeladen werden.

CHEMISCHE GEFAHREN

Zersetzung beim Verbrennen unter Bildung reizender Rauche.

ARBEITSPLATZGRENZWERTE

TLV:(als Stearat) 10 mg/m?(als TWA) Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation.

INHALATIONSGEFAHREN

Eine belästigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden.

LECKAGE

Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

Chemische Eigenschaften

Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin. nonflammable used in baby dusting powder(s) and as tablet lubricant.

Verwenden

Magnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.

Vorbereitung Methode

Magnesium stearate is prepared either by the interaction of aqueous solutions of magnesium chloride with sodium stearate or by the interaction of magnesium oxide, hydroxide, or carbonate with stearic acid at elevated temperatures.

synthetische

Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.

Definition

Mg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.

Allgemeine Beschreibung

Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Pharmazeutische Anwendungen

Magnesium stearate is widely used in cosmetics, foods, and pharmaceutical formulations. It is primarily used as a lubricant in capsule and tablet manufacture at concentrations between 0.25% and 5.0% w/w. It is also used in barrier creams.

Sicherheitsprofil

Slightly toxic by ingestion. Spontaneously combustible. When heated to decomposition it emits acrid smoke and toxic fumes.

Sicherheit(Safety)

Magnesium stearate is widely used as a pharmaceutical excipient and is generally regarded as being nontoxic following oral administration. However, oral consumption of large quantities may produce a laxative effect or mucosal irritation.
No toxicity information is available relating to normal routes of occupational exposure. Limits for heavy metals in magnesium stearate have been evaluated in terms of magnesium stearate worstcase daily intake and heavy metal composition.
Toxicity assessments of magnesium stearate in rats have indicated that it is not irritating to the skin, and is nontoxic when administered orally or inhaled.
Magnesium stearate has not been shown to be carcinogenic when implanted into the bladder of mice.
LD50 (rat, inhalation): >2 mg/L
LD50 (rat, oral): >10 g/kg

Lager

Magnesium stearate is stable and should be stored in a well-closed container in a cool, dry place.

Inkompatibilitäten

Incompatible with strong acids, alkalis, and iron salts. Avoid mixing with strong oxidizing materials. Magnesium stearate cannot be used in products containing aspirin, some vitamins, and most alkaloidal salts.

Regulatory Status

GRAS listed. Accepted as a food additive in the USA and UK. Included in the FDA Inactive Ingredients Database (oral capsules, powders, and tablets; buccal and vaginal tablets; topical preparapreparations; intravitreal implants and injections). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Listed on the US TSCA inventory.

Magnesiumdistearat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Magnesiumdistearat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 941)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386
marketing1@neostarunited.com China 12210 58
Changzhou Rokechem Technology Co., Ltd.
18758118018
sales001@rokechem.com China 255 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 2989 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 153 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850
hbjbtech@163.com China 1000 58
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+undefined15030412209
admin@juchuangchem.com China 387 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335
admin@hbsaisier.cn China 981 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618740459177
sarah@tnjone.com China 1142 58
Yujiang Chemical (Shandong) Co.,Ltd.
+86-17736087130 +86-18633844644
catherine@yjchem.com.cn China 969 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58

557-04-0(Magnesiumdistearat)Verwandte Suche:


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