L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
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- CAS-Nr.
- 159190-45-1
- Englisch Name:
- L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- Synonyma:
- L-NIL HCL;L-NIL DIHYDROCHLORIDE;L-N6-(1-Iminoethyl)lysine;OQIBCXRAFAHXMM-KLXURFKVSA-N;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-Lysine ω-acetamidine dihydrochloride;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;LNIL dihydrochloride,L NIL dihydrochloride;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
- CBNumber:
- CB5353543
- Summenformel:
- C8H18ClN3O2
- Molgewicht:
- 223.7
- MOL-Datei:
- 159190-45-1.mol
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
- Aggregatzustand
- White to off-white solid.
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC
50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both
in vitro and
in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan
L. major.
Verwenden
L-N
6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Biochem/physiol Actions
Selective inhibitor of inducible nitric oxide synthase (iNOS).
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 25)Lieferanten
159190-45-1()Verwandte Suche:
- L-NIL HCL
- L-N6-(1-IMINOETHYL)-LYSINE 2HCL
- L-N6-(1-IMINOETHYL)LYSINE, DIHCL
- L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
- L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)
- L-Lysine ω-acetamidine dihydrochloride
- L-NIL DIHYDROCHLORIDE
- OQIBCXRAFAHXMM-KLXURFKVSA-N
- L-N6-(1-Iminoethyl)lysine
- LNIL dihydrochloride,L NIL dihydrochloride
- 159190-45-1
- Nitric Oxide Synthase
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- L to O
- BioChemical
- Biochemicals and Reagents
- Nitric Oxide
