4-O-β-D-Galaktopyranosyl-D-glucitol

LACTITOL Struktur
585-86-4
CAS-Nr.
585-86-4
Bezeichnung:
4-O-β-D-Galaktopyranosyl-D-glucitol
Englisch Name:
LACTITOL
Synonyma:
Lactit;Lactnol;Lactite;LACTITOL;Importal;Lactit M;Lactosit;Finlac DC;D-Lactitol;Lactiobiosit
CBNumber:
CB5363096
Summenformel:
C12H24O11
Molgewicht:
344.31
MOL-Datei:
585-86-4.mol

4-O-β-D-Galaktopyranosyl-D-glucitol Eigenschaften

Schmelzpunkt:
146°
alpha 
D23 +14° (c = 4 in water)
Siedepunkt:
788.5±60.0 °C(Predicted)
Dichte
1.69±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
Löslichkeit
Slightly soluble in ethanol (95%) and ether. Soluble 1 in 1.75 of water at 20°C; 1 in 1.61 at 30°C; 1 in 1.49 at 40°C; 1 in 1.39 at 50°C.
pka
12.84±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Geruch (Odor)
odorless
LogP
-3.11

Sicherheit

Giftige Stoffe Daten 585-86-4(Hazardous Substances Data)

4-O-β-D-Galaktopyranosyl-D-glucitol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Lactitol occurs as white orthorhombic crystals. It is odorless with a sweet taste that imparts a cooling sensation. It is available in powdered form and in a range of crystal sizes. The directly compressible form is a water-granulated product of microcrystalline aggregates.

Verwenden

Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. It is also used medically as a laxative.

Vorbereitung Methode

Lactitol is produced by the catalytic hydrogenation of lactose.

Pharmazeutische Anwendungen

Lactitol is used as a noncariogenic replacement for sucrose. It is also used as a diluent in solid dosage forms.(1) A direct-compression form is available,(2,3) as is a direct-compression blend of lactose and lactitol. Lactitol is also used therapeutically in the treatment of hepatic encephalopathy and as a laxative.

Sicherheit(Safety)

Lactitol is regarded as a nontoxic and nonirritant substance. It is not fermented significantly in the mouth, and is not cariogenic.It is not absorbed in the small intestine, but is broken down by microflora in the large intestine, and is metabolized independently of insulin. In large doses it has a laxative effect; therapeutically, 10–20 g daily in a single oral dose is administered for this purpose.
LD50 (mouse, oral): >23 g/kg
LD50 (rat, oral): 30 g/kg

Lager

Lactitol as the monohydrate is nonhygroscopic and is stable under humid conditions. It is stable to heat and does not take part in the Maillard reaction. In acidic solution, lactitol slowly hydrolyzes to sorbitol and galactose. Lactitol is very resistant to microbiological breakdown and fermentation. Store in a well-closed container. When the compound is stored in an unopened container at 25°C and 60% relative humidity, a shelf-life in excess of 3 years is appropriate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

4-O-β-D-Galaktopyranosyl-D-glucitol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-O-β-D-Galaktopyranosyl-D-glucitol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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585-86-4(4-O-β-D-Galaktopyranosyl-D-glucitol)Verwandte Suche:


  • 4-O-(beta-D-galacto-hexopyranosyl)-D-glucitol
  • 4-O-?D-Galactopyranosyl-D-glucitol monohydrate
  • LACTITOL
  • 4-O-(β-Galactosyl)-D-glucitol
  • D-Glucitol, 4-O-.beta.-D-galactopyranosyl-
  • 4-O-B-D-GALACTOPYRANOSYL-D-GLUCITOL MONOHYDRATE
  • Lactnol
  • 4-β-D-galactopyranosyl-D-glucito1
  • Lactite
  • 4-O-beta-D-Galactopyranosyl-D-glucitol
  • Lactitol anhydrous
  • D-Glucitol, 4-O-b-D-galactopyranosyl-
  • D-4-O-β-D-Galactopyranosyl-glucitol
  • D-Lactitol
  • Finlac DC
  • Importal
  • Lactiobiosit
  • Lactit
  • Lactit M
  • Lactitol ACM 50
  • Lactitol LC 0
  • Lactosit
  • 4-O-β-D-Galaktopyranosyl-D-glucitol
  • D-Glucitol, 4-O-β-D-galactopyranosyl-
  • LACTITOL USP/EP/BP
  • 585-86-4 LACTITOL C12H24O11
  • Lactitol monohidrate
  • 585-86-4
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