Testosteron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R61:Kann das Kind im Mutterleib schädigen.
R11:Leichtentzündlich.
R19:Kann explosionsfähige Peroxide bilden.
R20:Gesundheitsschädlich beim Einatmen.
R40:Verdacht auf krebserzeugende Wirkung.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Testosterone (Item No.15645) is an analytical reference material categorized as an anabolic androgenic steroid. Testosterone is an endogenous metabolite of androstenedione (Item Nos.
ISO60161 |
15874) and estradiol (Item Nos.
ISO60155 |
10006315). Anabolic steroids, including testosterone, have been used to enhance physical performance in athletes. Testosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
Chemische Eigenschaften
white crystalline odourless solid
Verwenden
Secreted by the testis and is converted to dihydrotestosterone in the target tissue where is appears to mediate many of the biological actions of testosterone.
CONTROLLED SUBSTANC
Definition
ChEBI: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-41C-5..
Allgemeine Beschreibung
Testosterone, 17β-hydroxyandrost-4-en-3-one, is a naturally occurring androgen in men. Inwomen, it mainly serves as a biosynthetic precursor to estradiolbut also has other hormonal effects. It is rapidly metabolizedto relatively inactive 17-ones, however,preventing significant oral activity. Testosterone is availablein a transdermal delivery system (patch), a gel formulation, abuccal system, and as implantable pellets.
Hazard
A confirmed carcinogen.
Health Hazard
Controls secondary male sex characteristics Maintains functional competence of male reproductive ducts and glands
Increases protein anabolism; maintains spermatogenesis; inhibits follotropin
Increases male sex behavior; increases closure of epiphyseal plates
Biologische Aktivität
Endogenous androgen receptor agonist.
Sicherheitsprofil
Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intraperitoneal route. Human teratogenic effects by unspecified route: developmental abnormalities of the urogenital system. Experimental reproductive effects. Human mutation data reported. Workers engaged in manufacture and packagmg have shown effects from this hormone, e.g., enlargement of the breasts in male workers. A promoter. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a drug for the treatment of hypogonadism and metastatic breast cancer.
läuterung methode
Crystallise testosterone from aqueous acetone, hexane or isoPrOH. The long needles that separated from EtOH/AcOH were used for X-ray crystallography [Roberts et al. J Chem Soc Perkin Trans II 1978 1973.] The acetate [1045-69-8] crystallises from MeOH or aqueous Me2CO, with m 140-141o and [] D 20 +87.8o (c 1, EtOH). [Ruzicka et al. Helv Chim Acta 18 1478 1935 and 19 99, 842 1936, Beilstein 8 IV 974.]
Testosteron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Mangandioxid
Acetylacetone
3β,11α-Dihydroxy-5α-androstan-17-one
Androstan-?17-?one, 3,?7-?dihydroxy-?, (3β,?5α,?7β)?-
Boldenon
6A-HYDROXY-ANDROST-4-ENE-3,17-DIONE
5-Androstenedione
Androsta-1,4-dien-3,17-dion
3-β-Hydroxy-5-α-androstan-17-on
(8R,9S,10R,13S,14S,17S)-10,13-dimethylspiro[1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-3,2'-1,3-dioxolane]-17-ol
Androst-4-en-3-one, 17-[(tetrahydro-2H-pyran-2-yl)oxy]-, (17β)-
14A-HYDROXYTESTOSTERONE--DEA*SCHEDULE II I ITEM
Testosteronenantat
4-Androstenediol
testololactone
3-Ethoxyandrosta-3,5-dien-17β-ol
Androst-4-en-3,17-dion
Downstream Produkte
