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Chlortetracyclin Produkt Beschreibung

Chlortetracycline Struktur
57-62-5
CAS-Nr.
57-62-5
Bezeichnung:
Chlortetracyclin
Englisch Name:
Chlortetracycline
Synonyma:
Aurofac;Biovetin;acronize;Uromycin;duomycin;flamycin;aureocina;biomitsin;auromycin;Biomycin A
CBNumber:
CB5408663
Summenformel:
C22H23ClN2O8
Molgewicht:
478.88
MOL-Datei:
57-62-5.mol

Chlortetracyclin Eigenschaften

Schmelzpunkt:
168-169°
alpha 
D23 -275.0° (methanol)
Dichte
1.2833 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
2-8°C
pka
pKa 3.3 (Uncertain)
CAS Datenbank
57-62-5(CAS DataBase Reference)
EPA chemische Informationen
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy- 6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-(57-62-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
WGK Germany  1
RTECS-Nr. QI7750000
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

Chlortetracyclin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

Verwenden

Chlortetracycline was the first reported member of the tetracycline class, isolated from Streptomyces aureofaciens in 1948. Chlortetracyclines heralded the early wave of antibiotic discoveries from microbes and after 50 years are still widely used as pharmaceuticals. Chlortetracycline is a pigment and, like most pigments, is extremely sensitive to environmental and storage conditions. Commercial chlortetracycline may contain significant levels of degradation products.

Definition

ChEBI: A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens.

Antimicrobial activity

It is slightly less active than tetracycline against many bacteria, with the exception of Gram-positive organisms.

Pharmazeutische Anwendungen

7-Chlortetracycline. A fermentation product of certain strains of Streptomyces aureofaciens. Formulated as the hydrochloride or the free base for oral or topical application.

Pharmakokinetik

Oral absorption:30–60%
Cmax 500 mg oral:2.5–7 mg/L:
Plasma half-life: 5–6 h
Volume of distribution: c.2 L/kg
Plasma protein binding: 47–65%
Absorption is relatively poor compared with other tetracyclines. It undergoes rapid metabolism and is largely eliminated by biliary excretion, with only a small proportion eliminated via the kidney. Despite this, chlortetracycline is not recommended for patients in renal failure, since accumulation occurs as a consequence of the half-life increase to approximately 7–11 h.

Clinical Use

Its uses are those common to the group. It has also been used topically in the management of recurrent aphthous ulcers of the mouth, but experience is limited and the mechanism of action is unknown.

Nebenwirkungen

Side effects are typical of the group. Contact hypersensitivity has been reported with topical application to abraded skin and varicose ulcers.

Sicherheitsprofil

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cland NOx. See also TETRACYCLINE.

Veterinary Drugs and Treatments

There are a variety of approved chlortetracycline products for use in food animals. It may also be useful in treating susceptible infections in dogs, cats, birds and small mammals (not Guinea pigs). For more information, refer to the Doses section below.

läuterung methode

Aureomycin is dehydrated by azeotropic distillation of its solution with toluene. On cooling, the anhydrous material crystallises out and is recrystallised from *C6H6, then dried under vacuum at 100o over paraffin wax. (If it is crystallised from MeOH, it contains MeOH which is not removed on drying.) [Stephens et al. J Am Chem Soc 76 3568 1954, Laskin & Chan Biochem Biophys Res Commun 14 137 1964]. [Beilstein 14 IV 2631.]

Chlortetracyclin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlortetracyclin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 101)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 913 58

57-62-5(Chlortetracyclin)Verwandte Suche:


  • acronize
  • aureocina
  • aureomycina-377
  • aureomykoin
  • biomitsin
  • chlortetracycline
  • Aurofac 10
  • Biomycin A
  • Biovetin
  • Chlortetracyclinum
  • Clortetraciclina
  • Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-
  • Streptomyces aureofaciens antibiotic
  • CHLORTETRACYCLINE HCL ( VETERINARY)
  • auromycin
  • Chlorotetracycline HCL(Vet)
  • ChlorotetracyclineF.G.powder
  • F.G.granulated
  • Chlorotetracyclinebaseand/orunspecifiedsalts
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
  • aureomycine
  • chlortetracycline,calcium salt
  • Feed aureomycin powder
  • Chlorotetracycline, Chlortetracycline
  • Chlortetracyclin
  • Uromycin
  • Chlortetracycline Selective Supplement,Chlorotetracycline, Chlortetracycline
  • Chlortetracycline, AureoMycin
  • Chlortetracycline base
  • AureoMycin, Chlorotetracycline, BioMycin
  • chrysomykine
  • duomycin
  • flamycin
  • ydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4s-(4alpha,4aalpha,5a
  • 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • CHLOROTETRACYCLINE
  • Acronize PD
  • Aureocarmyl
  • Aureociclin
  • Aureomicina
  • Aureomycin-R
  • Aurofac
  • Chlortetracycline (15%)
  • 10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-6
  • 7-chlorotetracycline
  • Chlortetracycline Premix
  • 57-62-5
  • C22H23ClN2O8
  • C22H23ClN2O3
  • C22H23CIN2O8
  • C22H23CL1N2O8
  • -
  • PHARMACEUTICALS
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