GW7647

GW7647 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPARα It activates human PPARα, PPARγ, and PPARδ with EC₅₀ values of 0.006, 1.1 and 6.2 μM, respectively, in a GAL4-PPAR binding assay. Similar EC₅₀ values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.

Verwenden

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

• in defatting medium to treat primary human hepatocytes
• to test its effect on the glycolytic function in cardiomyocytes
• to test its effect on infant mouse heart
• in breast cancer MDA-MB-231 cells to activate PPARs

Definition

ChEBI: A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.

Allgemeine Beschreibung

A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC₅₀ = 6 nM, 1.1 μM and 6.2 μM for human; 1 nM, 1.3 μM and 2.9 μM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.

Biologische Aktivität

Potent and highly selective PPAR α agonist (EC 50 values are 6, 1100 and 6200 nM for human PPAR α , PPAR γ and PPAR δ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro . Has lipid-lowering effects following oral administration in vivo .

GW7647 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GW7647 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

265129-71-3()Verwandte Suche:

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• 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropa
• GW7647, >=98%
• Propanoic acid, 2-[[4-[2-[[(cyclohexylaMino)carbonyl](4-cyclohexylbutyl)aMino]ethyl]phenyl]thio]-2-Methyl-
• GWalpha 7647
• GW 7647X
• 2-((4-(2-(((Cyclohexylamino)carbonyl)-(4-cyclohexylbutyl)amino)ethyl)phenyl)thio)-2-methylpropanoicacid
• 2-[[4-[2-[[(CYCLOHEXYLAMINO)CARBONYL](4-CYCLOHEXYLBUTYL)AMINO]ETHYL]PHENYL]THIO]-2-METHYLPROPANOIC ACID
• 2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID
• GW7647
• GW647
• GW7647; GW 7647
• CS-761
• GW7647 - CAS 265129-71-3 - Calbiochem
• 2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
• 265129-71-3
• C29H46N2O3S
• BioChemical
• Cell Biology
• Cell Signaling and Neuroscience
• PPAR and RXR Regulators
• Gene Regulation and Expression
• Intracellular receptor