CRAC Channel Inhibitor III, Pyr6 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca
2+ release-activated Ca
2+) channel-mediated SOCE (store-operated Ca
2+ entry) in RBL-2H3 cells (IC
50 = 490 nM by Fura-2; peak current density pA/pF = -1.31 and -7.50, respectively, with or without 3 μM Pyr6 by whole cell clamp), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca
2+ entry) upon carbachol (Cat. No.
212385) stimulation in TRPC3-expressing HEK293 cells (IC
50 = 18.46 μM; by Fura-2; pA/pF = -9.50 and -18.50, respectively, with or without 3 μM Pyr6). A great complement to Pyr2 (Cat. No.
203890), Pyr3 (Cat. No.
648490), and Pyr10 (Cat. No.
648494) in Ca
2+ signaling studies.
Biochem/physiol Actions
Cell permeable: yes
CRAC Channel Inhibitor III, Pyr6 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
