O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI

132489-69-1

CAS-Nr.: 132489-69-1

Englisch Name:: O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI

Synonyma:: (Z)-Pugnac;(Z)-PUGNAc min. 99%;PUGNAc extrapure, 95%;O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI;acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate;n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime;O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate;(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%

CBNumber:: CB5503122

Summenformel:: C15H19N3O7

Molgewicht:: 353.33

MOL-Datei:: 132489-69-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 95

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Eigenschaften

Schmelzpunkt:: 172-175°C

Dichte: 1.53

storage temp.: -20°C

Löslichkeit: Soluble in DMSO (up to 35 mg/ml)

Aggregatzustand: solid

pka: 11.85±0.70(Predicted)

Farbe: White

BRN: 4274031

Stabilität:: Moisture and Temperature Sensitive

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

WGK Germany	3
HS Code	29329990

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352	BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (K_i = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B

Biologische Aktivität

O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Upstream-Materialien And Downstream Produkte

Upstream-Materialien

O-(2-ACETAMIDO-3,4,6-TRI-O-ACETYL-D-GLUCOPYRANOSYLIDENE)AMINO N-PHENYL CARBAMATE 2-ACETAMIDO-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE 1-N,3,4,6-TETRAACETATE 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-D-GLUCOHYDROXIMO-1,5-LACTONE

Downstream Produkte

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 95)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	6000	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

132489-69-1()Verwandte Suche:

3-Methyl-3H-adenin Ethyl-N-hydroxyacetimidat

(Z)-Pugnac
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%
(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
(Z)-PUGNAc min. 99%
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
2-(AcetylaMino)-2-deoxy-N-[[(phenylaMino)carbonyl]oxy]-D-gluconiMidic Acid δ-Lactone
(1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid delta-lactone
n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime
acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate
O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
(5R,6R,7S,8R,Z)-6,7-Dihydroxy-8-(hydroxymethyl)-2,3-dioxo-N-((phenylcarbamoyl)oxy)-1,4-oxazocane-5-carbimidic acid
D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-
PUGNAc extrapure, 95%
132489-69-1
Carbohydrates & Derivatives
Glycosidase Inhibitors
Inhibitors