LDN-57444

LDN-57444 Struktur
668467-91-2
CAS-Nr.
668467-91-2
Englisch Name:
LDN-57444
Synonyma:
CS-988;LDN-57444;UCH-L1 Inhibitor;LDN 57444, >=98%;LDN-57444/LDN57444;LDN-57444 USP/EP/BP;UCH-L1 INHIBITOR;LDN57444;UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem;3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
CBNumber:
CB5804575
Summenformel:
C17H11Cl3N2O3
Molgewicht:
397.64
MOL-Datei:
668467-91-2.mol

LDN-57444 Eigenschaften

Siedepunkt:
534.4±60.0 °C(Predicted)
Dichte
1.50±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: soluble16mg/mL
Aggregatzustand
solid
pka
-2.57±0.20(Predicted)
Farbe
Yellow
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher N
R-Sätze: 50/53
S-Sätze: 60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

LDN-57444 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.

Verwenden

LDN 57444 is an inhibitor of UCH-L1, an enzyme expressed by certain lung tumor-derived cell lines, suggesting that this enzyme plays a role in tumor progression.

Biochem/physiol Actions

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1

LDN-57444 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


LDN-57444 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 106)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
sales@alphabiopharm.com China 886 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30256 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10523 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58

  • LDN-57444
  • 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime)
  • LDN-57444/LDN57444
  • 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
  • 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) LDN 57444
  • 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione
  • UCH-L1 Inhibitor
  • (Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
  • LDN 57444, >=98%
  • UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem
  • CS-988
  • UCH-L1 INHIBITOR;LDN57444
  • LDN-57444 USP/EP/BP
  • 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
  • 668467-91-2
  • Inhibitors
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