Tacedinaline
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- CAS-Nr.
- 112522-64-2
- Englisch Name:
- Tacedinaline
- Synonyma:
- acetyldinaline;CI 994;CS-617;Cl-994;Goe 5549;PD 123654;CI994, >=99%;Tacedinaline;N-Acetyldinaline;CI994 (Tacedinaline)
- CBNumber:
- CB5855542
- Summenformel:
- C15H15N3O2
- Molgewicht:
- 269.3
- MOL-Datei:
- 112522-64-2.mol
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Tacedinaline Eigenschaften
- Schmelzpunkt:
- 216.1 °C
- Siedepunkt:
- 450.6±30.0 °C(Predicted)
- Dichte
- 1.322±0.06 g/cm3(Predicted)
- RTECS-Nr.
- CU8702023
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- Löslichkeit
- Soluble in DMSO
- pka
- 13.15±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- off-white
- Sensitive
- Air Sensitive
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- VAZAPHZUAVEOMC-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher |
Xi |
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R-Sätze: |
36 |
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S-Sätze: |
26 |
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WGK Germany |
3 |
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HS Code |
2924.29.7790 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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Sicherheit |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Tacedinaline Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tum
or cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.
Definition
ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al
o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Biologische Aktivität
Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .
Tacedinaline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tacedinaline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 188)Lieferanten
112522-64-2()Verwandte Suche:
- Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
- Tacedinaline
- CI 994
- N-Acetyldinaline
- 4-AcetaMido-N-(2-aMinophenyl)benzaMide
- Cl-994(Tacedinalin,N-Acetyldinalin)
- CI994 (Tacedinaline)
- CI-994 4-Acetylamino-N-(2'-aminophenyl)benzamide
- Goe 5549
- PD 123654
- CI994, >=99%
- 4-acetylamino-n-(2'-aminophenyl)benzamide
- CI 994 - PD 123654 | Tacedinaline
- -aminophenyl)benzamide
- PD-123654;CI-994;PD123654
- CS-617
- Cl-994
- CI-994 (Acetyldinaline,PD123654)
- 4-Acetamido-N-(2-aminophenyl)benzamide >
- Tacedinaline (CI994)
- Tacedinaline USP/EP/BP
- Tacedinaline (GOE-5549, PD-123654, CI-994
- acetyldinaline
- Goe5549,CI-994,Tacedinaline,inhibit,HDAC,CI 994,Inhibitor,Histone deacetylases,Apoptosis,Goe 5549
- 112522-64-2
- Inhibitors
- Inhibitor
- Apoptosis Inducers