AS 604850

AS 604850 Struktur
648449-76-7
CAS-Nr.
648449-76-7
Englisch Name:
AS 604850
Synonyma:
CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302;PI 3-Kγ Inhibitor II AS-604850 AS604850;PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
CBNumber:
CB5972768
Summenformel:
C11H5F2NO4S
Molgewicht:
285.22
MOL-Datei:
648449-76-7.mol

AS 604850 Eigenschaften

Dichte
1.71
storage temp. 
2-8°C
Löslichkeit
DMSO: >10mg/mL
Aggregatzustand
solid
pka
7.07±0.20(Predicted)
Farbe
off-white
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 43
S-Sätze: 36/37
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

AS 604850 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R43:Sensibilisierung durch Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

AS 604850 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AS 604850 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 103)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5739 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860
18522618860@163.com China 694 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58

648449-76-7()Verwandte Suche:


  • AS 604850
  • PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
  • PI 3-Kinase Inhibitor (AS604850) B-0302
  • (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
  • 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
  • AS-604850;AS 604850
  • PI 3-Kγ Inhibitor II
  • 5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione
  • PI 3-Kinase Inhibitor (AS604850)
  • CS-538
  • AS604850; AS 604850; AS-604850
  • PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
  • 2,4-Thiazolidinedione, 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-
  • AS 604850 USP/EP/BP
  • PI 3-Kγ Inhibitor II AS-604850 AS604850
  • 5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
  • 648449-76-7
  • C11H5F2NO4S
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
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