Fentanyldihydrogencitrat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White Powder
Verwenden
Fentanyl citrate can be used as an analgesic.
Definition
ChEBI: The citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A mu-opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable canc
r pain. It is also widely used as the analgesic component of balanced anaesthesia.
Biologische Aktivität
Potent and selective μ -opioid receptor agonist (K i values are 7.0, 151 and 470 nM for μ -, δ - and κ -opioid receptors respectively). Displays antinociceptive activity in vivo .
Clinical Use
A fentanyl patch is available for the treatment of severe chronic pain. This dosage form delivers
fentanyl transdermally and provides effective analgesia for periods of up to 72 hours. In 1999,
fentanyl also became available in a lollipop dose form for absorption from the oral cavity.
Fentanyl's short duration of action after parenteral dose is caused by redistribution rather than by
metabolism or excretion. Repeated doses of fentanyl can result in accumulation and toxicities.
Elderly patients usually are more sensitive to fentanyl and require lower doses.
Opioids have a wide spectrum of P-glycoprotein (P-gp) activity, acting as both substrates and
inhibitors, which might contribute to their varying CNS-related effects. Although fentanyl,
sufentanil, and alfentanil did not behave as P-gp substrates, they inhibited the in vitro
P-gp–mediated efflux of drugs known to be P-gp transported, such as digoxin, increasing their
blood levels and the potential for important drug interactions by inhibition of P-gp efflux
transporter.
Sicherheitsprofil
Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also PHENTANYL.
Fentanyldihydrogencitrat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
