Saxagliptin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration an
d has a pharmacokinetic profile compatible with once daily dosing.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hex
ne-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Clinical Use
Saxagliptin, previously identified as BMS-477118, is an oral
hypoglycemic of the dipeptidyl peptidase-4 (DPP-4) inhibitor class
developed by Bristol-Myers Squibb for the treatment of type 2 diabetes.
DPP-IV is the primary enzyme responsible for degradation
of incretins, such as glucagon-like peptide-1 (GLP-1), which is a
hormone responsible for the glucose-dependent stimulation of
insulin in humans. Inhibitors of DPP-IV serve as effective glucose
regulators by increasing the endogenous concentration of GLP-1.
Saxagliptin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
