3-ISOBUTYL-1-METHYLXANTHINE
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- CAS-Nr.
- 28822-58-4
- Englisch Name:
- 3-ISOBUTYL-1-METHYLXANTHINE
- Synonyma:
- IBMX;MIX;3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione;IMX;SC 2964;NSC 165960;IBMX(NSC165960;3-Isobutyl-1-methylx;Isobutylmethylxanthine;Methylisobutylxanthine
- CBNumber:
- CB6263892
- Summenformel:
- C10H14N4O2
- Molgewicht:
- 222.24
- MOL-Datei:
- 28822-58-4.mol
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3-ISOBUTYL-1-METHYLXANTHINE Eigenschaften
- Schmelzpunkt:
- 200-201 °C(lit.)
- Siedepunkt:
- 363.42°C (rough estimate)
- Dichte
- 1.2042 (rough estimate)
- Brechungsindex
- 1.6500 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: 1 M with gentle warming
- Aggregatzustand
- powder
- pka
- 8.61±0.70(Predicted)
- Farbe
- off-white
- BRN
- 247859
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- APIXJSLKIYYUKG-UHFFFAOYSA-N
- CAS Datenbank
- 28822-58-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
ZD8500000 |
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| HS Code |
29335990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
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3-ISOBUTYL-1-METHYLXANTHINE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Needles with Yellow Cast
Verwenden
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Allgemeine Beschreibung
3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.
Biologische Aktivität
Phosphodiesterase inhibitor (IC 50 values are 13, 18, 19, 32 and 50 μ M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC 50 = 1.3 μ M).
läuterung methode
Recrystallise it from aqueous EtOH. [Beilstein 26
3-ISOBUTYL-1-METHYLXANTHINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-ISOBUTYL-1-METHYLXANTHINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 248)Lieferanten
28822-58-4()Verwandte Suche:
- 3,7-Dihydro-1-methyl-3-(2-methy
- 3-isobutyl-1-methyl-1H-purine-2,6(3H,9H)-dione
- 3-isobutyl-1-methyl-3,9-dihydro-1H-purine-2,6-dione
- 3-isobutyl-1-methyl-7H-purine-2,6-dione
- 3-isobutyl-1-methyl-7H-purine-2,6-quinone
- 3-Isobutyl-1-methyxanthine
- 3-isobutyl-1-methyl-7H-xanthine
- 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
- 3-ISOBUTYL-1-METHYL-2,6(1H,3H)-PURINEDIONE
- 3-ISOBUTYL-1-METHYLXANTHINE
- 3-ISOBUTYL-I-METHYLXANTHINE
- 3-ISOBUTYL-1-METHYLXANTHINE SIGMAULTRA
- Isobutyl-1-methylxanthine
- 3-ISOBUTYL-1-METHYLXANTHINE,ULTRAPURE
- 3-Isobutyl-1-methylxanthine, HPLC 99%
- 3-ISOBUTYL-1-METHYLXANTHINE (CRYSTALLINE)
- 3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
- NSC 165960
- 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
- 3-Isobutyl-1-methylxanthine 99+%
- 3-Isobutyl-1-methylxanthine,1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
- 3-Isobutyl-1-methylx
- (3-isobutyl-1-Methylxanthine,IBMX)
- 3-Isobutyl-1-Methylxanthine, 99+% 1GR
- 3,9-Dihydro-1-Methyl-3-(2-Methylpropyl)-
- 3-Isobutyl-1-Methyl-1H-purine-2,6(3H,7H)-dione
- 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-
- 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-6-dione
- 3-Isobutyl-1-methylanxthine
- 3-isobutyl-1-methyl-xanthin
- IMX
- Isobutylmethylxanthine
- Methylisobutylxanthine
- SC 2964
- Xanthine, 3-Isobutyl-1-methyl-
- 1-METHYL-3-ISOBUTYL XANTHINE
- 1-Methyl-3-isobutylxanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
IBMX
MIX
- 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem
- IBMX(NSC165960
- IMX; ISOBUTYLMETHYLXANTHINE; METHYLISOBUTYLXANTHINE; NSC165960; SC2964
- 1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-
- 3-ISOBUTYL-1-METHYLXANTHINE USP/EP/BP
- 1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
- 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
- MIX
- IBMX
- IBMX,Phosphodiesterase (PDE),inhibit,Inhibitor
- 3-isobutyl-1-methyl-9H-purine-2,6-dione
- 28822-58-4
- Non-specific inhibitor of cAMP and cGMP phosphodiesterases.
- KETONE
- BioChemical
- Chiral Building Blocks
- Cell Biology
- Cell Signaling and Neuroscience
- Asymmetric Synthesis
- G Proteins and Cyclic Nucleotides
- Cyclic Nucleotide Metabolism
