Methoxyfluran Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche (Chlorwasserstoff, Fluorwasserstoff). Greift einige Arten von
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Exposition in hohen Konzentrationen kann zu Bewusstlosigkeit führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf Nieren mit nachfolgenden Nierenschäden.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe. Ausgelaufene Flüssigkeit in abdichtbaren Metallbehältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.
R-Sätze Betriebsanweisung:
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
colourless liquid
Verwenden
Methoxyflurane is a very potent and highly lipid soluble anesthetic agent. Methoxyflurane causes deep sedation and it has been used as a patient controlled analgesic for painful procedures in children. Methoxyflurane is a significant respiratory depressant.
Definition
ChEBI: An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.
Biologische Funktion
Methoxyflurane (Penthrane) is the most potent inhalational
agent available, but its high solubility in tissues limits
its use as an induction anesthetic. Its pharmacological
properties are similar to those of halothane with some
notable exceptions. For example, since methoxyflurane
does not depress cardiovascular reflexes, its direct myocardial
depressant effect is partially offset by reflex
tachycardia, so arterial blood pressure is better maintained.
Also, the oxidative metabolism of methoxyflurane
results in the production of oxalic acid and fluoride concentrations
that approach the threshold of causing renal
tubular dysfunction. Concern for nephrotoxicity has
greatly restricted the use of methoxyflurane.
Allgemeine Beschreibung
Methoxyflurane is a volatile liquid (bp＝105°C) with a highblood:gas partition coefficient and thus a slow induction andprolonged recovery. Approximately 75% of the drug undergoesmetabolism yielding dichloroacetate, difluoromethoxyacetate,oxalate, and fluoride ions. The intrarenal inorganicfluoride concentration, as a result of renal defluorination, maybe responsible for the nephrotoxicity seen with methoxyflurane.Both the concentration of F
- generated and the durationfor which it remained elevated were factors in the developmentof methoxyflurane nephrotoxicity. Methoxyfluranewas removed from the U.S. market in 2000 because of saferalternatives. Both isoflurane and enflurane produce less fluorideion upon metabolism than methoxyflurane.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER may be sensitive to prolonged exposure to light.
Health Hazard
Methoxyflurane exhibited low to very lowacute toxicity via inhalation, slightly lowerthan that of ethrane. Oral toxicity was low tomoderate depending on the species. Inhala tion of its vapors at 1.5–2% by volumeconcentrations in air can cause anesthesia inhumans. The toxic symptoms are similar tothose of ethrane, and the target organs areprimarily the central nervous system, kidney,and liver. At subanesthetic concentrations of0.3–0.5% by volume in air, its exposure tohumans for 1 hour resulted in the onset oflow toxicity. The sites of biological effectswere in the kidney.
LC50 value, inhalation (mice): 17,500 ppm/2 hr
LD50 value, oral (mammals): 3600 mg/kg
The liquid may be an irritant to theeyes. The teratomeric properties of this com pound were observed in rats and mice. Thesymptoms were embryo deaths and develop mental abnormalities in the urogenital andmusculoskeletal systems.
No carcinogenic actions in animals orhumans have been reported. The histidinereversion–Ames test for mutagenicity wasinconclusive.
Brandgefahr
2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER is combustible.
Clinical Use
Methoxyflurane is seldom used because of its propensity to cause renal toxicity. It is
the most potent agent, and it has the highest solubility in blood. Induction
and recovery would be expected to be slow. Chemically, it is rather unstable, and as much as 50%
of an administered dose can be metabolized. Toxic metabolites significantly limit its utility as a
general anesthetic.
Methoxyfluran Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
