Calciumhydrogenorthophosphat

Calcium phosphate dibasic Struktur
7757-93-9
CAS-Nr.
7757-93-9
Bezeichnung:
Calciumhydrogenorthophosphat
Englisch Name:
Calcium phosphate dibasic
Synonyma:
DICALCIUM PHOSPHATE;MONOCALCIUM PHOSPHATE;DIBASIC CALCIUM PHOSPHATE;CALCIUM HYDROGEN PHOSPHATE;Anhydrous Dibasic Calcium Phosphate;CALCIUM ORTHOPHOSPHATE;Monetite;calciumdibasicphosphate;CALCIUM PHOSPHATE, DIBASIC;CALCIUM HYDROGEN ORTHOPHOSPHATE
CBNumber:
CB6344120
Summenformel:
CaHO4P
Molgewicht:
136.06
MOL-Datei:
7757-93-9.mol

Calciumhydrogenorthophosphat Eigenschaften

Schmelzpunkt:
370°C(decomposition)
Dichte
2.306(16℃)
RTECS-Nr.
TB8528000
storage temp. 
2-8°C
Löslichkeit
Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
Aggregatzustand
gel (aged)
Farbe
White
PH
7 (10g/l, H2O, 20°C) suspension
Wasserlöslichkeit
Sparingly soluble in water, practically insoluble in cold water.
Merck 
13,1697
Solubility Product Constant (Ksp)
pKsp: 7
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
FUFJGUQYACFECW-UHFFFAOYSA-L
LogP
-2.148 (est)
CAS Datenbank
7757-93-9(CAS DataBase Reference)
EPA chemische Informationen
Calcium hydrogen phosphate (7757-93-9)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-24/25-22
WGK Germany  3
TSCA  Yes
HS Code  2835 25 00
Giftige Stoffe Daten 7757-93-9(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Calciumhydrogenorthophosphat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

Anhydrous dibasic calcium phosphate is a white, odorless, tasteless powder or crystalline solid. It occurs as triclinic crystals.

Physikalische Eigenschaften

White triclinic crystal; density 2.92 g/cm3 (anhydrous) and 2.31 g/cm3 (dihy drate); hardness 3.5 Mohs; decomposes on heating; inosluble in water and alcohol; KSP 2.7x10-7; soluble in dilute mineral acid.

Verwenden

Replenisher (calcium); pharmaceutic aid (tablet base).

Vorbereitung Methode

Calcium phosphates are usually prepared by reacting very pure phosphoric acid with calcium hydroxide, Ca(OH)2 obtained from limestone, in stoichiometric ratio in aqueous suspension followed by drying at a temperature that will allow the correct hydration state to be achieved. After drying, the coarse-grade material is obtained by means of a classification unit; the fine particle-size material is obtained by milling. Dibasic calcium phosphate, anhydrous, may also be prepared by spray-drying.

Landwirtschaftliche Anwendung

Dicalcium phosphate (CaHPO4) is made from calcium carbonate and phosphoric acid. It contains 34% citrate- soluble phosphorus pentoxide (P2O5). It is not commonly used as a fertilizer, but is used as a supplement to animal feed.

Pharmazeutische Anwendungen

Anhydrous dibasic calcium phosphate is used both as an excipient and as a source of calcium in nutritional supplements. It is used particularly in the nutritional/health food sectors. It is also used in pharmaceutical products because of its compaction properties, and the good flow properties of the coarse-grade material. The predominant deformation mechanism of anhydrous dibasic calcium phosphate coarse-grade is brittle fracture and this reduces the strain-rate sensitivity of the material, thus allowing easier transition from the laboratory to production scale. However, unlike the dihydrate, anhydrous dibasic calcium phosphate when compacted at higher pressures can exhibit lamination and capping. This phenomenon can be observed when the material represents a substantial proportion of the formulation, and is exacerbated by the use of deep concave tooling. This phenomenon also appears to be independent of rate of compaction.
Anhydrous dibasic calcium phosphate is abrasive and a lubricant is required for tableting, for example 1% w/w magnesium stearate or 1% w/w sodium stearyl fumarate.
Two particle-size grades of anhydrous dibasic calcium phosphate are used in the pharmaceutical industry. Milled material is typically used in wet-granulated or roller-compacted formulations. The ‘unmilled’ or coarse-grade material is typically used in directcompression formulations.
Anhydrous dibasic calcium phosphate is nonhygroscopic and stable at room temperature. It does not hydrate to form the dihydrate.
Anhydrous dibasic calcium phosphate is used in toothpaste and dentifrice formulations for its abrasive properties.

Sicherheitsprofil

Skin and eye irritant. A nuisance dust.

Sicherheit(Safety)

Dibasic calcium phosphate anhydrous is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a relatively nontoxic and nonirritant material.

Lager

Dibasic calcium phosphate anhydrous is a nonhygroscopic, relatively stable material. Under conditions of high humidity it does not hydrate to form the dihydrate.
The bulk material should be stored in a well-closed container in a dry place.

läuterung methode

Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].

Inkompatibilitäten

Dibasic calcium phosphate should not be used to formulate tetracyline antibiotics.
The surface of milled anhydrous dibasic calcium phosphate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH. However, reports suggest there are differences in the surface alkalinity/acidity between the milled and unmilled grades of anhydrous dibasic calcium phosphate; the unmilled form has an acidic surface environment. This difference has important implications for drug stability, particularly when reformulating from, e.g. roller compaction to direct compression, when the particle size of the anhydrous dibasic calcium phosphate might be expected to change.
Dibasic calcium phosphate dihydrate has been reported to be incompatible with a number of drugs and excipients, and many of these incompatibilities are expected to occur with dibasic calcium phosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Calciumhydrogenorthophosphat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Calciumhydrogenorthophosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 484)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chongqing Chuandong Chemical (Group) Co. Ltd.
+86-13637972665 +86-13637972665
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+86-15175982296 15175982296;
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BLiT (Hefei)Chemical Co.,Ltd

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+86-13474506593 +86-13474506593
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+86-518-85110578 +8618805133257
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+86-0551-65418679 +86-18949832763
info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58

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