Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat

Tolmetin sodium Struktur
35711-34-3
CAS-Nr.
35711-34-3
Bezeichnung:
Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat
Englisch Name:
Tolmetin sodium
Synonyma:
TOLECTIN;Sodium tolmetin;TOLMETIN SODIUM;Tolmetin Sodium Salt;Tolmetin sodium USP/EP/BP;sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate;sodium:2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate;1-Methyl-5-p-toluoyl-1H-pyrrole-2-acetic acid sodium salt;1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid sodium salt;SodiuM 2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetate
CBNumber:
CB6397353
Summenformel:
C15H14NNaO3
Molgewicht:
279.27
MOL-Datei:
35711-34-3.mol

Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Eigenschaften

Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Tolmetin Sodium is a non-steroidal anti-inflammatory drug.

Pharmakokinetik

Tolmetin sodium is rapidly and almost completely absorbed on oral administration, with peak plasma levels being attained within the first hour of administration. It has a relatively short plasma half-life of approximately 1 hour because of extensive first-pass metabolism, involving hydroxylation of the p-methyl group to the primary alcohol, which is subsequently oxidized to the dicarboxylic acid.

Clinical Use

Tolmetin is synthesized straightforwardly from 1-methylpyrrole. It was introduced in the United States in 1976 and like other NSAIDs, inhibits prostaglandin biosynthesis. Tolmetin, however, also inhibits polymorph migration and decreases capillary permeability. Its anti-inflammatory activity, as measured in the carrageenan-induced rat paw edema and cotton pellet granuloma assays, is intermediate between those of phenylbutazone and indomethacin.

Nebenwirkungen

The most frequently adverse reactions are those involving the GI tract (e.g., abdominal pain, discomfort, and nausea) but appear to be less than those observed with aspirin. The CNS effects (e.g., dizziness and drowsiness) also are observed. Few cases of overdosage have been reported, but in such cases, recommended treatment includes elimination of the drug from the GI tract by emesis or gastric lavage and elimination of the acidic drug from the circulatory system by enhancing alkalinization of the urine with sodium bicarbonate.

Stoffwechsel

This metabolite is inactive in standard in vivo anti-inflammatory assays. The free acid (pKa = 3.5) is highly bound to plasma proteins (99%), and excretion of tolmetin and its metabolites occurs primarily in the urine.Approximately 15 to 20% of an administered dose is excreted unchanged and 10% as the glucuronide conjugate of the parent drug. Conjugates of the dicarboxylic acid metabolite account for the majority of the remaining administered drug.

Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 49)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3959 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30255 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 50001 58
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
info@yuhaochemical.com China 9394 52
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12338 58
Shanghai Hekang Biotechnology Co., Ltd. 18939837085
youchemicals@gmail.com China 1813 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973186 4009686088
3193328036@qq.com China 18352 68

35711-34-3(Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat)Verwandte Suche:


  • TOLMETIN SODIUM
  • sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
  • TOLECTIN
  • 1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid sodium salt
  • 1-Methyl-5-p-toluoyl-1H-pyrrole-2-acetic acid sodium salt
  • Sodium tolmetin
  • SodiuM 2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetate
  • tolmetin sodium:sodium 1-methyl-5-(4-methylbenzoyl)-1h-pyrrole-2-acetate
  • sodium:2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
  • Tolmetin Sodium Salt
  • Tolmetin sodium USP/EP/BP
  • 35711-34-3
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