Meglumin

Meglumine Struktur
6284-40-8
CAS-Nr.
6284-40-8
Bezeichnung:
Meglumin
Englisch Name:
Meglumine
Synonyma:
N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber:
CB6411710
Summenformel:
C7H17NO5
Molgewicht:
195.21
MOL-Datei:
6284-40-8.mol

Meglumin Eigenschaften

Schmelzpunkt:
129-131.5 °C (lit.)
Siedepunkt:
331.88°C (rough estimate)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Dichte
1.2669 (rough estimate)
RTECS-Nr.
LZ4295770
Brechungsindex
-16.5 ° (C=2, H2O)
storage temp. 
2-8°C
Löslichkeit
H2O: 0.1 g/mL, clear, colorless
Aggregatzustand
Crystalline Powder
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
Farbe
White to almost white
PH
11 (10g/l, H2O, 20℃)
Optische Aktivität
[α]20/D 16.5±0.5°, c = 2% in H2O
Wasserlöslichkeit
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP
-3.370 (est)
NIST chemische Informationen
N-methylglucamine(6284-40-8)
EPA chemische Informationen
Meglumine (6284-40-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 36/37/38
S-Sätze: 24/25
WGK Germany  3
3-10-23
Selbstentzündungstemperatur ~662 °F
TSCA  Yes
HS Code  29221980
Toxizität LD50 orally in Rabbit: > 5000 mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Meglumin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Verwenden

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Vorbereitung Methode

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmazeutische Anwendungen

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Sicherheit(Safety)

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

Lager

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

läuterung methode

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Inkompatibilitäten

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Meglumin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 689)Lieferanten
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SIMAGCHEM CORP
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6284-40-8(Meglumin)Verwandte Suche:


  • 1-Deoxy-1-(methylamino)hexitol
  • Glucitol, 1-deoxy-1-(methylamino)-, D-
  • D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
  • MEGLUMINE
  • 1-DEOXY-1-(METHYLAMINO)GLUCITOL
  • 1-DEOXY-1-METHYLAMINOSORBITOL
  • N-METHYL-D(-)-GLUCAMINE
  • Methylglucamine,99%
  • N-Methyl-D-glucamine
  • N-Methyl-D-Glucamine(Or) Meglumine
  • N-Methyl-D-glucamine Vetec(TM) reagent grade, 99%
  • D(-)-N-Methylglucamine for resolution of racemates for synthesis
  • N-Methyl-D-Glu
  • METHYL GLUCAMINE MEGLUMINE
  • MEGLUMINE, USP
  • N-Methylglucamine (Meglumine)
  • N-Methyl-D-Glucamine>99%
  • MeglumineAntimoniateBase
  • N-METHYL-D-GLUCANINE
  • MEGLUMINE(N-METHYLGLUCAMINE)
  • N-METHYLCYCLOHEXALAMINE
  • N-METHYL-D-GLUCAMINE USP
  • 1-(Methylamino)-1-deoxy-D-glucitol
  • 1-Methylamino-1-deoxy-D-glucitol
  • D-1-Deoxy-1-(methylamino)glucitol
  • MegluMine (AS)
  • Meglumine, 1-Deoxy-1-(methylamino)-D-glucitol, (2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol, 1-Deoxy-1-methylaminosorbitol
  • N-MethylglucaMin (MegluMine)
  • Meglumine (500 mg) (AS)
  • N-Methyl-D-glucaMine, 99% 100GR
  • N-Methyl-D-glucaMine, 99% 2.5KG
  • N-Methyl-D-glucaMine, 99% 500GR
  • MegluMine,USP,BP,EP
  • N-Methyl-D-glucaMine 99.0-100.5% (titration)
  • N-Methyl-D-glucaMine ReagentPlus(R), >=99.0% (T)
  • N-Methyl-D-glucaMine , 99.0%(T)
  • N-MethylglucaMine USP
  • D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF
  • Fosaprepitant Impurity H
  • C7H18NO5
  • methyl-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ammonium
  • ucamine
  • The most popular N-methylglucamine
  • N-Methyl-D-glucamine, 99%, reagent grade
  • N-Methyl-D-glucamine>
  • -D-gL
  • Meglumine, USP, EP, BP
  • Meglumine CPH4 5KG
  • Meglumine CPH4 PARENTEX 5KG
  • Meglumine USP/Ph.Eur/BP 5KG
  • Meglumine CDMF PARENTEX 500GM
  • Meglumine CDMF 500GM
  • Meglumine (AS) (1379140)
  • 1-deoxy-1-(methylamino)-d-glucito
  • Meglumin
  • Methylglucamin
  • Methylglucamine
  • D(-)-N-METHYLGLUCAMINE
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