ChemicalBook
Chinese english Germany Japanese Korea

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure Produkt Beschreibung

Aminopterin Struktur
54-62-6
CAS-Nr.
54-62-6
Bezeichnung:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure
Englisch Name:
Aminopterin
Synonyma:
AGPA;apga;nsc739;apga[qr];pteramina;ent-26079;nsc739[qr];Minopterin;Aminoperin;AMINOPTERIN
CBNumber:
CB6418254
Summenformel:
C19H20N8O5
Molgewicht:
440.41
MOL-Datei:
54-62-6.mol

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure Eigenschaften

Schmelzpunkt:
228-235 °C (dec.)
alpha 
18 º (c=1% in 0.1N NaOH)
Siedepunkt:
551.67°C (rough estimate)
Dichte
1.4378 (rough estimate)
Brechungsindex
1.6910 (estimate)
Flammpunkt:
87℃
storage temp. 
2-8°C
Löslichkeit
2 M NaOH: 50 mg/mL
Aggregatzustand
powder
pka
pKa 5.5 (Uncertain)
Farbe
yellow
Merck 
14,472
BRN 
69045
CAS Datenbank
54-62-6(CAS DataBase Reference)
EPA chemische Informationen
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl) methyl]amino]benzoyl]-(54-62-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+
R-Sätze: 61-28-63-26/27/28
S-Sätze: 53-28-36/37-45-36/37/39-22
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS-Nr. MA1050000
8-10-23
HazardClass  6.1(a)
PackingGroup  I
HS Code  29339900
Giftige Stoffe Daten 54-62-6(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R61:Kann das Kind im Mutterleib schädigen.
R28:Sehr giftig beim Verschlucken.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Chemische Eigenschaften

Dark Yellow Solid

Chemische Eigenschaften

Aminopterin is a white to yellow powder; commonly used as the dihydrate which forms clustersof yellow needles

Verwenden

A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.

Verwenden

antineoplastic, antirheumatic, folic acid antagonist

Definition

Differs slightly in structure from folic acid and antagonizes the utilization of folic acid by the body, an antimetabolite.

Allgemeine Beschreibung

Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.

Health Hazard

An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.

Sicherheitsprofil

Poison by ingestion and intraperitoneal routes. Human and experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Human systemic effects by ingestion: gastrointestinal. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx,.

mögliche Exposition

Aminopterin is used as a medicine (as a folic acid antagonist), rodenticide, and agricultural chemical.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

läuterung methode

Purify aminopterin by recrystallisation from H2O. It has properties similar to those of methotrexate (above). It has UV at max 244, 290 and 355nm ( 18600, 21300 and 12000) in H2O at pH 1; 260, 284 and 370nm ( 28500, 26400 and 8600) in H2O at pH 13. [Seeger et al. J Am Chem Soc 71 1753 1949, Angier & Curran J Am Chem Soc 8 1 2814 1959, Blakley The Biochemistry of Folic Acid and Related Pteridines, North-Holland Publ Co., Amsterdam, NY, pp 157-163 1969.] For small quantities, chromatograph it on DEAE cellulose with a linear gradient of ammonium bicarbonate pH 8 and increase the molarity from 0.1 to 0.4. Monitoring is by following the UV absorption of the fractions. For larger quantities, a near boiling solution of aminopterin (5g) in H2O (400mL) is slowly treated with small portions of MgO powder (~0.7g, calcined magnesia) with vigorous stirring until a small amount of MgO remained undissolved and the pH rises from 3-4 to 7-8. Charcoal (1g) is added to the hot solution and filtered immediately through a large sintered glass funnel of medium porosity and lined with a hot wet pad of Celite (~2-3 mm thick). The filtrate is cooled in ice, and the crystals of the Mg salt are collected by filtration and recrystallised from boiling H2O (200mL). The crystals are washed with EtOH and dried in vacuo. The Mg salt is redissolved in boiling H2O (200mL) and carefully acidified with vigorous agitation with AcOH (2mL). Pure aminopterin (3g) separates in fine yellow needles (dihydrate) which are easily filtered. The solid is washed with cold H2O, then Me2CO and dried in vacuo. If a trace of impurity is still present as shown by DEAE cellulose chromatography or TLC, repetition of the process will remove it; see UV above. [Loo J Med Chem 8 139 1965, Beilstein 26 IV 3831.] CARCINOGENIC.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or wastepharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 124)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Standardpharm Co. Ltd.
0714-3992388
yxzy@std-med.net CHINA 13064 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96506 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202,021-54308259
+86-21-64545202 info@hanhonggroup.com China 43260 64

54-62-6(N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsure)Verwandte Suche:


  • nsc739[qr]
  • pteramina
  • pteramina(czech)[qr]
  • Methotrexate Related CoMpound B
  • Methotrexate Related Compound B (75 mg) ((S)-2-{4-[2,4-diaminopteridin-6yl)methylamino]benzoamido}pentanedioic acid)
  • Minopterin
  • Methotrexate EP IMpurity B
  • (S)-2-(4-(((2,4-diaMinopteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
  • Methotrexate IMpurity B
  • Venglustat L-malate
  • Aminopterin Ready Made Solution
  • 4-amino-4-deoxypteroylglutamate
  • 4-amino-folicaci
  • 4-aminofolicacid[qr]
  • 4-amino-pga[qr]
  • 4-aminopteroylglutamicacid[qr]
  • 4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci
  • AGPA
  • ai3-26079[qr]
  • aminopteridine
  • aminopterinum
  • aminopterinum[qr]
  • a-ninopterin
  • apga
  • apga[qr]
  • ent-26079
  • ent-26079[qr]
  • kyselina4-aminolistova
  • kyselina4-aminolistova(czech)[qr]
  • kyselina4-aminopteroylglutamova
  • kyselina4-aminopteroylglutamova(czech)[qr]
  • kyselinan-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-l(+)-glutamova
  • kyselinan-(p-((2,4-diamino-6-pteridinylmethyl)benzoyl)-l(+)-glutamova(czech)
  • l-glutamicacid,n-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-[qr]
  • n-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-l-glutamicacid
  • n-(4-((2,4-diamino-6-pteridyl)-methyl)amino)benzoyl)-l-glutamicacid[qr]
  • n-(p-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-glutamicacil-[qr]
  • n-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-l-glutamicaci
  • METHOTREXATE RC B ( AMINOPTERIN)
  • Methotrexate Impurity 2(EP-B)
  • nsc739
  • AMINOPTERIN
  • AMINOPTERINE
  • 4-AMINO-PGA
  • 4-AMINOFOLIC ACID
  • 4-AMINOPTEROYLGLUTAMIC ACID
  • 4-AMINOPTEROYL-L-GLUTAMIC ACID
  • AMINOPTERIN CELL CULTURE TESTED
  • AMINOPTERIN (50X) HYBRI-MAXGAMMA-IRRADIA TED
  • AMINOPTERIN 2-HYDRATE
  • AMINOPETERIN
  • 4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA
  • L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylaminobenzoyl-
  • (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
  • Aminopterin: (Aminopteridine)
  • 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid
  • Aminoperin
  • 2-(4-((2,4-diaminopteridin-6-yl)methylamino)benzamido)pentanedioic acid
Copyright 2019 © ChemicalBook. All rights reserved