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(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat)

T-2 TOXIN Struktur
21259-20-1
CAS-Nr.
21259-20-1
Bezeichnung:
(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat)
Englisch Name:
T-2 TOXIN
Synonyma:
toxint2;Toxin T 2;hothecene;nsc138780;T-2 TOXIN;T-2 toxins;alerate[qr];FUSARITOXIN;t-2mycotoxin;Insariotoxin
CBNumber:
CB6469458
Summenformel:
C24H34O9
Molgewicht:
466.53
MOL-Datei:
21259-20-1.mol
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(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Eigenschaften

Schmelzpunkt:
151.5℃
alpha 
D26 +15° (c = 2.58 in ethanol)
Siedepunkt:
489.35°C (rough estimate)
Dichte
1.1942 (rough estimate)
Brechungsindex
1.6230 (estimate)
Flammpunkt:
2 °C
storage temp. 
−20°C
Löslichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
Aggregatzustand
powder
pka
13.24±0.70(Predicted)
Farbe
white
Merck 
13,9872
IARC
3 (Vol. 31, Sup 7) 1987
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,T,Xn,F
R-Sätze: 26/27/28-38-36-20/21/22-11
S-Sätze: 28-36/37-45-36-26-16-36/37/39-22
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS-Nr. YD0100000
F  10-21
HazardClass  6.1(a)
PackingGroup  I
HS Code  29329990
Giftige Stoffe Daten 21259-20-1(Hazardous Substances Data)
Toxizität LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
Sicherheit
P262 Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R38:Reizt die Haut.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Beschreibung

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemische Eigenschaften

White powder

Verwenden

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Allgemeine Beschreibung

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Sicherheitsprofil

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NEOSOLANIOL

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 113)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
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sales@aladdinsci.com United States 57511 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76

21259-20-1((3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat))Verwandte Suche:

3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))- (3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) 12,13-Epoxytrichothec-9-en-3α,4β,15-triol-4,15-diacetat Tetrahydro-4-methyl-2-(2-methylprop-1-enyl)pyran 3-Methyl-2-(3-methylbut-2-enyl)butan-1,3-diyldiacetat
  • 4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol
  • 8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol
  • T-2 LienoMycin
  • T-2 Toxin, froM FusariuM tricinctuM
  • 12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8
  • 12,13-trichothecene
  • 3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene
  • 3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
  • 3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup9)-tric
  • 3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-(sup9)-trich
  • 3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxytrichothec-9-ene
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol[qr
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol
  • 4-beta,15-diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxy
  • 4beta,8alpha,15-tetrol,12,13-epoxy-,4,15-diacetate8-trichothec-9-ene-3alph
  • 8-(3-methylbutyryloxy)-diacetoxy-scirpeno
  • 8-(3-Methylbutyryloxy)diacetoxyscirpenol
  • 8-(3-methylbutyryloxy)-diacetoxyscirpenol
  • 8-(3-methylbutyryloxy)-diacetoxyscirpenol[qr]
  • 8alpha-(3-methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol[qr]
  • 8-isovalerate
  • a9-tricothecene[qr]
  • alerate[qr]
  • fusariotoxinet2
  • fusariotoxinet2[qr]
  • t(sub2)-trichothecene[qr]
  • t-2mycotoxin
  • t-2mycotoxin[qr]
  • t2-trichothecene[qr]
  • Toxin T 2
  • toxint2
  • trichothec-9-ene
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
  • 8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol
  • T2 Toxin / Fusariotoxin T 2 / Insariotoxin / Mycotoxin T 2
  • hothecene
  • Insariotoxin
  • insariotoxin[qr]
  • isaritoxin[qr]
  • -isovalerate
  • nsc138780
  • nsc138780[qr]
  • othecene[qr]
  • Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-
  • trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,4,15-diacetate8-(3-methylbutan
  • Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
  • trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol,12,13-epoxy-,4,15-diacetate
  • MYCOTOXIN TRICHOTHECENE 2
  • MYCOTOXIN T 2
  • T-2 TOXIN
  • (3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE)
  • 4BETA,15-DIACETOXY-3ALPHA-HYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE
  • FUSARIOTOXIN
  • FUSARIOTOXIN T 2
  • FUSARITOXIN
  • EPOXYTRICHOTHECENE
  • T-2 toxin from fusarium sp
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