CFTR Inhibitor III, OXO-172 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable CFTR
inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR
inh-172 (420 μM vs. 17 μM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR
inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 μM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC
50 = 1.4 μM vs. 0.38 μM with CFTR
inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 μM).
CFTR Inhibitor III, OXO-172 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
