ChemicalBook
Chinese english Germany Japanese Korea

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Produkt Beschreibung

Saccharin sodium  Struktur
128-44-9
CAS-Nr.
128-44-9
Bezeichnung:
1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz
Englisch Name:
Saccharin sodium
Synonyma:
sucra;dagutan;madhurin;kristallose;willosetten;cristallose;crystallose;SYNCAL (R) GS;solublegluside;saccharinnatrium
CBNumber:
CB6485865
Summenformel:
C7H5NNaO3S
Molgewicht:
206.17
MOL-Datei:
128-44-9.mol

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Eigenschaften

Schmelzpunkt:
>300°C
FEMA 
2997 | SACCHARINE, SODIUM SALT
storage temp. 
0-6°C
Löslichkeit
H2O: 1 M at 20 °C, clear, colorless
Aggregatzustand
neat
Wasserlöslichkeit
>=10 g/100 mL at 20 ºC
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
WINXNKPZLFISPD-UHFFFAOYSA-M
CAS Datenbank
128-44-9(CAS DataBase Reference)
EPA chemische Informationen
1,2-Benzisothiazol- 3(2H)-one, 1,1-dioxide, sodium salt(128-44-9)

Sicherheit

S-Sätze: 24/25
WGK Germany  2
RTECS-Nr. DE4550000

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

white powder

Chemische Eigenschaften

Saccharin is a crystalline solid with a sweet taste (500 times sweeter than sugar).

Chemische Eigenschaften

Saccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.

Chemische Eigenschaften

Saccharine sodium salt has no odor, but has an intensly sweet taste.

Verwenden

Sweetener (non-nutritive).

Vorbereitung Methode

Saccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.

Trademarks

Sucaryl (Ross).

Allgemeine Beschreibung

Odorless white crystals or crystalline powder. Aqueous solution is neutral or alkaline to litmus, but not alkaline to phenolphthalein. Effloresces in dry air. Intensely sweet taste.

Air & Water Reaktionen

Water soluble.

Reaktivität anzeigen

Saccharin sodium may react with oxidizing agents. . Very weak base in aqueous solution.

Hazard

The use of saccharin is being limited due to possible carcinogenicity.

Brandgefahr

Flash point data are not available for Saccharin sodium , but Saccharin sodium is probably combustible.

Pharmazeutische Anwendungen

Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and intraperitoneal routes. A promoter. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, Na2O, and NOx.

Sicherheit(Safety)

There has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg

mögliche Exposition

The information provided has to do, primarily, with the manufacturing of saccharin. Saccharin has been used as a nonnutritive sweetening agent. At one point the United States consumption pattern for all forms of saccharin has been estimated as 45% in soft drinks; 18% in tabletop sweeteners; 14% in fruits, juices, sweets, chew- ing gum, and jellies; 10% in cosmetics and oral hygiene products; 7% in drugs, such as coating on pills; 2% in tobacco; 2% in electroplating; and 2% for miscellaneous uses. Human exposure to saccharin occurs primarily through ingestion because of its use in many dietic foods and drinks and some personal hygiene products, including toothpastes and mouthwashes. The general public is exposed to saccharin, especially by persons required to reduce sugar intake.

Lager

Saccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.

Versand/Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz- ardous material, Technical Name Required.

Inkompatibilitäten

Saccharin sodium does not undergo Maillard browning.

Inkompatibilitäten

Dust may form explosive mixture with air. Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Waste disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contami- nant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

Regulatory Status

Accepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 228)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1173 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21714 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 699 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58

128-44-9(1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz)Verwandte Suche:


  • Sodium 1,1-dioxo-1,2-benzothiazol-2-id-3-one
  • 2-Sodio-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
  • o-Benzoic acid sulfimide sodium
  • o-Benzoic Sulfimide Sodium Salt Saccharin Sodium Salt
  • o-SulfobenziMide SodiuM Salt 
  • benzo[d]isothiazol-3(2H)-one 1,1-dioxide, sodiuM salt
  • Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide
  • o-SulfobenziMide SodiuM Salt Dihydrate, 98.0%,(LC&T
  • kristallose
  • madhurin
  • o-sulfonbenzoicacidimidesodiumsalt
  • saccharinnatrium
  • saccharoidumnatricum
  • sodium1,2benzisothiazolin-3-one-1,1-dioxide
  • sodium2-benzosulphimide
  • sodiumbenzosulphimide
  • sodiumo-benzosulfimide
  • sodiumo-benzosulphimide
  • sodiumsaccharide
  • sodiumsaccharinate
  • sodiumsaccharine
  • solublegluside
  • 1,2-Benzothiazol-3(2H)-one 1,1-dioxide sodium salt
  • sucra
  • sulphobenzoicimide,sodiumsalt
  • willosetten
  • 2,3-DIHYDRO-3-OXOBENZISOSULFONAZOLE HYDRATE
  • 2,3-DIHYDRO-3-OXOBENZISOSULFONAZOLE SODIUM SALT, HYDRATE
  • 2,3-DIHYDRO-1,2-BENZISOTHIAZOL-3-ONE-1,1-DIOXIDE SODIUM SALT HYDRATE
  • 2-SULFOBENZOIC ACID IMIDE SODIUM SALT HYDRATE
  • O-SULFOBENZIMIDE SODIUM SALT
  • O-SULFOBENZIMIDE SODIUM SALT, HYDRATE
  • O-BENZOIC ACID SULFIMIDE SODIUM SALT HYDRATE
  • O-BENZOIC SULPHIMIDE SODIUM SALT HYDRATE
  • SACCHARINE SODIUM
  • SACCHARINE-SODIUM HYDRATE
  • SACCHARIN SODIUM
  • SACCHARIN SODIUM 450X
  • SACCHARIN SODIUM SALT
  • SACCHARIN SODIUM SALT, HYDRATE
  • sodium dihydrate
  • Saccharin sodium, Saccharin sodium dihydrate
  • Saccharin sldium
  • 1,2-benzisothiazolin-3-one,1,1-dioxide,sodiumsalt
  • artificialsweeteningsubstanzgendorf450
  • cristallose
  • crystallose
  • dagutan
  • SACCHARIN SODIUM SALT N-HYDRATE
  • SACCHARIN, SOLUBLE
  • SYNCAL (R) GS
  • SODIUM SACCHARIN
  • SACCHARIN SODIUM SALT CRYSTALLINE
  • Saccharin Socium Dihydrate USP/FCC, Granular
  • Saccharin Sodium BP98/USP24
  • O-BENZOIC SULFIMIDE SODIUM SALT 2-HYDRATE
  • O-SULFOBENZIMIDE(SACCHARIN)
  • SACCHARIN INSOLUBLE(O-SULFBENZIMIDE)
Copyright 2019 © ChemicalBook. All rights reserved