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3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol Produkt Beschreibung

Phentolamine Struktur
50-60-2
CAS-Nr.
50-60-2
Bezeichnung:
3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol
Englisch Name:
Phentolamine
Synonyma:
dibasin;regitipe;regitine;Rogitine;c7337ciba;fentolamin;Fentolamine;PHENTOLAMINE;phentalamine;phenotolamine
CBNumber:
CB6665216
Summenformel:
C17H19N3O
Molgewicht:
281.35
MOL-Datei:
50-60-2.mol

3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol Eigenschaften

Schmelzpunkt:
174-175°
Siedepunkt:
424.02°C (rough estimate)
Dichte
1.0510 (rough estimate)
Brechungsindex
1.6500 (estimate)
pka
pKa 7.7 (Uncertain)
CAS Datenbank
50-60-2(CAS DataBase Reference)

Sicherheit

Giftige Stoffe Daten 50-60-2(Hazardous Substances Data)

3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-adrenergic.

Definition

ChEBI: A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used fo the treatment of hypertension.

Indications

Human erectile tissue has a population of membrane receptors that are predominantly of the -adrenoceptor subtype. Phentolamine (Vasomax) is a nonselective - adrenoceptor blocking agent (see Chapter 11), and like other such agents, it has been used to treat ED. Nonselective adrenoceptor antagonists may provoke a reflex that increases both sympathetic outflow and the release of norepinephrine.

Trademarks

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

Allgemeine Beschreibung

Phentolamine isthe more effectiveα -blocker.

Clinical Use

Phentolamine isused to prevent or control hypertensive episodes that occurin patients with pheochromocytoma. It also has been used incombination with papaverine to treat impotence.

Clinical Use

Phentolamine has been used orally and intracavernosally in the treatment of ED. Following oral administration, phentolamine has a plasma half-life of about 30 minutes and a duration of action of 2 to 4 hours. An intracavernosal injection of phentolamine results in the drug reaching maximum serum levels in about 20 to 30 minutes. It is rapidly metabolized. Phentolamine has been used in combination with papaverine, chlorpromazine, and vasoactive peptides in the treatment of ED.

Nebenwirkungen

Side effects of phentolamine are dose related. It may cause orthostatic hypotension, reflex tachycardia, cardiac arrhythmias, and rarely, myocardial infarction. Phentolamine also may reduce sperm motility in vitro.

3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 62)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Jinan Haohua Industry Co., Ltd 0531-58773082 ;58773060
0531-58773099 sales@jnhaohua.com China 5585 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12123 58
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 18981987031
028-84555506 QQ:800101999 cdhxsj@163.com China 9978 58
Shanghai Kewel Chemical Co., Ltd. +86 (21) 6460-9169
+86 (21) 6460-9160 kewelchemexp@yahoo.com China 9834 50

50-60-2(3-((4,5-Dihydro-1H-imidazol-2-yl)-methyl)(4-methyl-phenyl)amino)phenol)Verwandte Suche:


  • phenotolamine
  • phentalamine
  • regitine
  • regitipe
  • PHENTOLAMINE
  • AKOS NCG1-0052
  • AURORA KA-7803
  • 3-(N-2-imidazolin-2-ylmethyl-p-toluidino)phenol
  • 3-[(4,5-dihydro-1h-imidazol-2-yl)methyl-(4-methylphenyl)-amino]phenol
  • PhentolamineMesilateBase
  • m-[N-[2-Imidazolin-2-ylmethyl]-p-toluidino] phenol
  • Phentolamine mesylas
  • Fentolamine
  • Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-
  • Rogitine
  • phentolaMine or its Mesylate
  • Phentolamine Imp.
  • Regilin/Rartin/Phentolamine mesylate
  • 2-(m-hydroxy-n-p-tolylanilinomethyl)-2-imidazoline
  • 2-(n-(m-hydroxyphenyl)-p-toluidinomethyl)imidazoline
  • 2-(n’-p-tolyl-n’-m-hydroxyphenylaminomethyl)-2-imidazoline
  • 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)-pheno
  • c7337ciba
  • dibasin
  • fentolamin
  • m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-pheno
  • 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)-
  • 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)-2-imidazolin
  • 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline
  • Phentolamine Impurity
  • 50-60-2
  • API
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