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Triclosan Produkt Beschreibung

CAS-Nr.3380-34-5
Bezeichnung:Triclosan
Englisch Name:Triclosan
Synonyma:
ch3565;IRGASAN;TROX-100;TRICLOSAN;TRICHLOSAN;Cloxifenol;ZilesanUW.;Irgacare MP;irgasandp300;Trichlorosan
CBNumber:CB6771432
Summenformel:C12H7Cl3O2
Molgewicht:289.54
MOL-Datei:3380-34-5.mol
Triclosan physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 56-60 °C(lit.)
Siedepunkt:: 290°C(lit.)
Dichte: 1.4214 (rough estimate)
Brechungsindex: 1.4521 (estimate)
storage temp. : Refrigerator
Löslichkeit: H2O: soluble12g/L at 20°C
pka: 7.9(at 25℃)
Aggregatzustand: Solid
Farbe: colorless or white
Wasserlöslichkeit: Soluble in ethanol, methanol, diethyl ether and sodium hydroxide solution (1M). Slightly soluble in water.
Merck : 14,9657
BRN : 2057142
Stabilität:: Stable. Incompatible with strong oxidizing agents.
InChIKey: XEFQLINVKFYRCS-UHFFFAOYSA-N
CAS Datenbank: 3380-34-5(CAS DataBase Reference)
NIST chemische Informationen: Triclosan(3380-34-5)
EPA chemische Informationen: Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- (3380-34-5)
Sicherheit
Kennzeichnung gefährlicher: Xi,N
R-Sätze:: 36/38-50/53-36/37/38
S-Sätze:: 26-39-46-60-61-24/25-22-36
RIDADR : UN 3077 9/PG 3
WGK Germany : 2
RTECS-Nr.: KO1100000
TSCA : Yes
HazardClass : 9
PackingGroup : III
HS Code : 29095000
Giftige Stoffe Daten: 3380-34-5(Hazardous Substances Data)

Triclosan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S46:Bei Verschlucken sofort ärztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Solid
Verwenden
Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.
Verwenden
anticonvulsant
Verwenden
Bacteriostat and preservative for cosmetic and detergent preparations.
Verwenden
triclosan is a preservative considered to have a low sensitizing potential in leave-on preparations.
Definition
ChEBI: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodo ants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Indications
Triclosan is a broad-spectrum antimicrobial compound. It was originally used in soaps, antiperspirants, and cosmetic toiletries as a germicide. Today, triclosan is incorporated into toothpaste because of its wide spectrum of antimicrobial activities and low toxicity.
Trademarks
Stri-Dex Cleansing Bar (Sterling Health U.S.A.); Stri-Dex Face Wash (Sterling Health U.S.A.).
Mechanism of action
Triclosan is active against a broad range of oral grampositive and gram-negative bacteria.The primary target of its antibacterial activity is the bacterial cell membrane. High concentrations cause membrane leakage and ultimately lysis of the bacterial cell. Effects at lower concentration are more subtle. Triclosan has been shown to bind to cell membrane targets and inhibit enzymes associated with the phosphotransferase and proton motive force systems.
Pharmakologie
Triclosan is retained in dental plaque for at least 8 hours, which in addition to its broad antibacterial property could make it suitable for use as an antiplaque agent in oral care preparations. However, the compound is rapidly released from oral tissues, resulting in relatively poor antiplaque properties as assessed in clinical studies of plaque formation.This observation is further corroborated by a poor correlation between minimal inhibitory concentration values generated in vitro and clinical plaque inhibitory properties of triclosan. Improvement of substantivity was accomplished by incorporation of triclosan in a polyvinyl methyl ether maleic acid copolymer (PVM/MA, Gantrez). With the combination of PVM/MA copolymer and triclosan, the substantivity of the triclosan was increased to 12 hours in the oral cavity.
Clinical Use
Triclosan plus copolymer is available in toothpaste. Commercially available dentifrice concentrations contain 0.3% triclosan and 2.0% PVM/MA copolymer.
Nebenwirkungen
Triclosan is a preservative used in health care and consumer products, including soaps, deodorants, mouthwashes, toothpastes, cosmetics, and topical medicaments. Ozkaya et al. described a case of suspected immune mediated Cou to triclosan. A 44-year-old female reported experiencing an immediate localized urticarial response after contact with numerous topical products. The use of a toothpaste had also resulted in swelling of her lips, tongue, and breathing difficulties. She also experienced lip swelling after kissing her husband who had used the same product and wheals involving her face after kissing friends on the cheek who had used certain topical products on their faces. The suspected products all contained triclosan 0.2%–0.5%. A severe localized urticarial reaction occurred with open testing to 2% triclosan within 15 minutes. No tests were performed to confirm an immunological mechanism; however, the authors suspected this to be the case because of a positive urticarial response to triclosan within 15 minutes, a history of angioedema to the triclosan-containing toothpaste, and because no immediate reactions were seen in five control subjects who were open tested to 2% triclosan.
Triclosan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Kupfer Kaliumhydroxid 2-Methoxyphenol 2,4-Dichlorphenol 2-Phenoxyanilin Diphenylether Brombenzol 2,6-Dichlorphenol Eisen
Downstream Produkte
Triclosan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 368)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571sales@zhonglanindustry.com CHINA 746 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21922 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684info@tnjchem.com China 1751 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086sales@tjzxchem.com CHINA 558 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20580 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 133 58
 
3380-34-5(Triclosan)Verwandte Suche:
Ammoniumperchlorat Trichlorsilan Ethylbenzol Dimethyl ether Trichlorisocyanursäure Ligroin Diphenylether Phenol Dicofol (ISO) Trichloroethane Phenolrot Trichlormethan Trichlorethylen Chlordifluormethan 3-Aminophenol 2-Butoxy-ethanol Diethylether Triclosan
2,4,4-trichloro-2-hydroxydiphenylether(irgasandp-300) 2’-hydroxy-2,4,4’-trichloro-phenylethe 5-chloro-2-(2,4-dichlorophenoxy)-pheno 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER 2,4,4-TRICHLORO-2-HYDROXYDIPHENYL ETHER TRICLOSAN trichloro-2'-hydroxydiphenylether TROX-100 TRICHLOSAN TRICLOSAN USP 2,4,4'Trichloro2'-HydroxyDiphenyaxide 2,4,4'-Trichloro-2-2' Hydroxy Diphenyl Ether Triclosan - CAS 3380-34-5 - Calbiochem ch3565 Cloxifenol ether,2’-hydroxy-2,4,4’-trichlorodiphenyl irgasandp300 2,4,4'-Trichloro-2'-hydroxydiphenyl ether (Triclosan) Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- TRICLOSAN,99%(BULK TRICHLOROHYDROXYDIPHENYLETHER 2,4,4'-Trichloro-2'-hydroxydiphenyl ether triclosan 2,4,4'-trichloro-2'-hydroxy-diphenyl-ether 5-chloro-2-(2,4-dichlorophenoxy)phenol 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Triclosan (4-Chloro-2-hydroxyphenyl)(2,4-dichlorophenyl) ether 5-Chloro-2-(2,4-dichlorophenoxy)phenol Triclosan (200 mg) TRICLOSAN (2',4,4'-TRICHLORO-2-HYDROXYDIPHENYL ETHER) - Building Blocks Antibiotics A to Z Antibiotics G-M Antibiotics BioChemical ZilesanUW. IRGASAN Irgacare MP TriMetazidine dichlorhydrate 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL F 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 5-Chloro-2-(2,4-dichlorophenoxy) phenol 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 97+% Triclosan 0.25 Irgasan, >=99% Trichlorosan IRGASAN >= 97.0% (HPLC) 5-Chloro-2-(2,4-dichlorophenoxy)phenol 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether Irgasan Three chloride Triclosan (Irgasan) 10 μg/mL in Cyclohexane C12H7Cl302=289.5 3380-34-5 C12H7Cl3O2 ClC6H3OC6H3Cl2OH Oxygen Compounds Phenols Organic Building Blocks Intermediates Miscellaneous Organics
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