Ethyl-bromacetat Chemische Eigenschaften,Einsatz,Produktion Methoden
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S1/2:Unter Verschluss und für Kinder unzugänglich aufbewahren.
Chemische Eigenschaften
Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is miscible with ethanol, ether, benzene and with other oxygenated and aromatic solvents, insoluble in water and partially decomposed by water.
Application
Ethyl Bromoacetate is used as a synthetic organic chemical intermediate as well as a pharmaceutical and agricultural intermediate. It is used in the synthesis of metabolites of carcinogenic PAHs. It is also used in the preparation of steroidal antiestrogens through cyclic condensation. Ethyl Bromoacetate is a reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.
synthetische
Ethyl bromoacetate is commonly synthesized by sulfuric acid catalyzed esterification of monobromoacetic acid (MBAA). After reaction completion, excess acid is washed out and the product purified via distillation under reduced pressure if necessary (Stenger, 1978; Korhonen, 1984).
Reaktionen
Ethyl bromoacetate on derivatisation reaction with p-t-butyl calix[4]arene yields 1,3-diester substituted calix[4]arene. It also undergoes Suzuki type cross-coupling reactions with arylboronic acids cocatalyzed by copper(I) oxide.
Allgemeine Beschreibung
Ethyl bromoacetate appears as a clear, colorless liquid. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.
Air & Water Reaktionen
Flammable. Insoluble in water.
Reaktivität anzeigen
Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Hazard
Toxic by ingestion, inhalation, and skin
absorption; strong irritant.
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Sicherheitsprofil
A poison. An irritant to
skin, eyes, and mucous membranes.
Questionable carcinogen with experimental
neoplastigenic data. Flammable liquid when
exposed to heat, flame, and oxidizers. Will
react with water or steam to produce toxic
and corrosive fumes. To fight fire, use water
as a fire blanket. When heated to
decomposition or on contact with acid or
acid fumes, it emits highly toxic fumes of
Br-. See also BROMIDES.
mögliche Exposition
Used for making pharmaceuticals; as
a warning gas in poisonous, odorless gasses; as a tear gas
Versand/Shipping
UN1603 Ethyl bromoacetate, Hazard class: 6.1;
Labels: 6.1-Poisonous materials.
läuterung methode
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.
Inkompatibilitäten
Vapor may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.
Ethyl-bromacetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE
ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE
5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE
3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE
ethyl 2-(2-aminothiazol-5-ylthio)acetate
3-METHYLBENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
3-O-TOLYL-PROPIONALDEHYDE
Ethyl 2-oxocyclopentylacetate
5-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID
2-Phenyl-1H-indole-1-acetic acid ,97%
(R)-3-Aminoquinuclidine dihydrochloride
3,4-DIMETHYLTHIENO[2,3-B]THIOPHENE-2-CARBALDEHYDE
(5-BROMO-1-BENZOFURAN-2-YL)METHANOL
3-(4-CHLORO-PHENYL)-PROPIONALDEHYDE
3,5-DIMETHYL-BENZOFURAN-2-CARBOXYLIC ACID
2-Piperazinone
N-(2-thioxo-4-oxothiazolidin)essigsure
3-CHLOROPHENOXYACETYL CHLORIDE
Ethyl-(methylsulfonyl)acetat
6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID
4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID
(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE
(4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID
(E)-Oct-2-en-1-ol
2-Methylcyclopropancarbonsure
MORPHOLINE-4-CARBOTHIOAMIDE
(S)-(+)-3-Quinuclidinol
Ethyl(4-butyry-2,3-dichloro)phenoxyacetate
Ethyl 3,5-dimethylbenzofuran-2-carboxylate ,95%
4-CHLORO-8-FLUORO-5H-PYRIMIDO[5,4-B]INDOLE
(4-FLUOROPHENOXY)ACETYL CHLORIDE
2-(CARBOXYMETHOXY)BENZOIC ACID
ethyl 2-(2-phenyl-1H-indol-1-yl)acetate
Ethyl-3,3-diethoxypropionat
3-COUMARANONE
ETHYL 2-(5-FORMYL-2,4-DIMETHYL-1H-PYRROL-3-YL)ACETATE
Chinuclidin-3-carbonsure
3,7-Dimethylocta-2,6-diensure
(R)-3-Quinuclidinol hydrochloride
