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Tramadol Produkt Beschreibung

Tramadol Struktur
27203-92-5
CAS-Nr.
27203-92-5
Bezeichnung:
Tramadol
Englisch Name:
Tramadol
Synonyma:
E 265;TRAMAL;CRISPIN;CG 315E;U 26255A;Tramadol;cis-Tramadol;Racemic tramadol;cis-(+-)-cyclohexano;TraMadoll Hydrochloride
CBNumber:
CB7104738
Summenformel:
C16H25NO2
Molgewicht:
263.38
MOL-Datei:
27203-92-5.mol

Tramadol Eigenschaften

Schmelzpunkt:
178-181 °C
Siedepunkt:
406.62°C (rough estimate)
Dichte
0.9903 (rough estimate)
Brechungsindex
1.4909 (estimate)
storage temp. 
2-8°C
Aggregatzustand
solid
pka
14.47±0.40(Predicted)
Farbe
white to off-white
CAS Datenbank
27203-92-5(CAS DataBase Reference)
NIST chemische Informationen
Tramadol(27203-92-5)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 22
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2

Tramadol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

Chemische Eigenschaften

Light Yellow Oil

Verwenden

An Analgesic. Used in the treatment of urinary incontinence

Trademarks

Trabar.

Allgemeine Beschreibung

Tramadol (Ultram) is an analgesic agent with multiple mechanismsof action. It is a weak μ-agonist with approximately30% of the analgesic effect antagonized by the opioid antagonistnaloxone. Used at recommended doses, it has minimaleffects on respiratory rate, heart rate, blood pressure, or GItransit times. Structurally, tramadol resembles codeine with the B, D, and E ring removed. The manufacturer states thatpatients allergic to codeine should not receive tramadol, becausethey may be at increased risk for anaphylactic reactions. Tramadol is synthesized and marketed as the racemicmixture of two (the [2S, 3S] [-] and the [2R, 3R] [+]) of thefour possible enantiomers. The (+) enantiomer is about30 times more potent than the (—) enantiomer; however,racemic tramadol shows improved tolerability.Neurotransmitter reuptake inhibition is also responsible forsome of the analgesic activity with the (—) enantiomer primarilyresponsible for norepinephrine reuptake and the (+)enantiomer responsible for inhibiting serotonin reuptake. Like codeine, tramadol is O-demethylated viaCYP2D6 to a more potent opioid agonist having 200-foldhigher affinity for the opioid receptor than the parent compound.Tramadol was initially marketed as nonaddictive, anda 3-year follow up study showed that the abuse potential isvery low, but not zero. Most abusers of tramadol have abusedopioid drugs in the past. Both enantiomers of tramadoland the major O-demethylated metabolite are proconvulsive,and tramadol should not be used in patients with a lowseizurethreshold including patients with epilepsy.

Tramadol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tramadol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 0)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate

27203-92-5(Tramadol)Verwandte Suche:


  • cis-(+-)-cyclohexano
  • TRAMAL
  • TRANS-(+/-)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL
  • CRISPIN
  • Cyclohexanol, 2-(dimethylamino)methyl-1-(3-methoxyphenyl)-, (1R,2R)-rel-
  • CG 315E
  • cis-Tramadol
  • Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1R,2R)-rel- (9CI)
  • Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, cis-(+-)-
  • Cyclohexanol, 2-[(dimethylamino)methyl]-1-(m-methoxyphenyl)- (8CI)
  • E 265
  • Racemic tramadol
  • U 26255A
  • Tramadol (base and/or unspecified salts)
  • (1R,2R)-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
  • Tramadol
  • (1S,2S)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
  • (1S-cis)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
  • (+)-(R,R)-trans-Tramadol
  • (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
  • TraMadol Hydrochloride IMp. A (EP) as Hydrochloride:
  • TraMadoll Hydrochloride
  • (1S,2S)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol
  • 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-cyclohexano
  • 27203-92-5
  • Tramadol
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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