Valspodar

Valspodar Struktur
121584-18-7
CAS-Nr.
121584-18-7
Englisch Name:
Valspodar
Synonyma:
Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber:
CB71116624
Summenformel:
C63H111N11O12
Molgewicht:
1214.62
MOL-Datei:
121584-18-7.mol

Valspodar Eigenschaften

Schmelzpunkt:
143-145°C
alpha 
D20 -255.1° (c = 0.5 in CHCl3)
Siedepunkt:
1290.1±65.0 °C(Predicted)
Dichte
1.015±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
pka
12.45±0.70(Predicted)
Aggregatzustand
powder
Farbe
white to beige
InChIKey
YJDYDFNKCBANTM-QCWCSKBGSA-N

Sicherheit

WGK Germany  3

Valspodar Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemische Eigenschaften

White Solid

Verwenden

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Cytotoxicity

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].

Valspodar Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Valspodar Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 123)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+16314854226
inquiry@bocsci.com United States 19743 58
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
sales@alphabiopharm.com China 886 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 967 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47464 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9340 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58

  • Valspodar
  • 3'-Keto-bmt(1)-Val(2)-cyclosporin a
  • Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
  • Sdz psc 833
  • Sdz-psc-833
  • Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]
  • 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
  • Valspodar(PSC-833,AMdray)
  • 6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D
  • 6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A
  • AMdray
  • Valpodar
  • PSC833(Valspodar)
  • Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-
  • Valspodar (PSC-833)
  • [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin
  • 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
  • PSC833 - Specific MDR1/P-gp Inhibitor
  • Valspodar, >=98%
  • CS-51
  • PSC 833; PSC-833; PSC833
  • Psc 833
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-6,9,18,24-Tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-enoyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • 121584-18-7
  • Intermediates & Fine Chemicals
  • Peptides
  • Pharmaceuticals
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