2-hydroxypentanedioic acid

2-hydroxypentanedioic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase.

2-hydroxypentanedioic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-hydroxypentanedioic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10269	58
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	3115	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Chengdu Chuangkecheng Biological Technology Co., Ltd.	028-028-0000000 13008177686	sales@ckcbiotech.com	China	723	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Beyond Pharmaceutical Co., Ltd	+86-0571-81953185; 15381198709 +86-15381198709	jasonyao@beyond-pharma.com	China	829	60

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• DL-ALPHA-HYDROXYGLUTARIC ACID DISODI
• (RS)-2-Hydroxypentanedioic acid disodium salt
• Disodium 2-hydroxyglutarate
• Pentanedioic acid, 2-hydroxy-, disodiuM salt
• 2-Hydroxypentanedioic Acid SodiuM Salt
• DL-α-Hydroxyglutaric acid disodiuM salt
• 2-Hydroxyglutaric Acid Disodium Salt
• 2-Hydroxyglutaric Acid DisodiuM Salt, contains up to 10% Methanol
• 2-HG (sodium salt)
• α-Hydroxyglutaric Acid (sodium salt)
• 2-Hydroxyglutaric Acid (sodium salt)
• DL-alpha-Hydroxyglutaric acid disodium salt
• DL-α-Hydroxyglutaric?acid?disodium?salt
• Disodium 2-hydroxypentanedioate
• α-Hydroxyglutaric acid (sodium)
• α-Hydroxyglutaric acid (disodium)
• D,L-2-Hydroxyglutaric acid disodium salt
• DL α Hydroxyglutaric acid disodium salt,DLαHydroxyglutaric acid disodium salt
• α-Hydroxyglutaric Acid (sodium salt)
• 40951-21-1
• Other APIs
• Aliphatics
• Inhibitors