(R)-MG132

(R)-MG132 Struktur
1211877-36-9
CAS-Nr.
1211877-36-9
Englisch Name:
(R)-MG132
Synonyma:
D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-;NSC60585;NSC 60585;MG-132(R);(R)-MG132;NSC-60585;MG-132(S,R,S);Z-Leu-D-leu-leu-al;(S,R,S)-(-)-MG-132;Cbz-L-leu-D-leu-L-leu-H
CBNumber:
CB72589829
Summenformel:
C26H41N3O5
Molgewicht:
475.62
MOL-Datei:
1211877-36-9.mol

(R)-MG132 Eigenschaften

Siedepunkt:
682.0±55.0 °C(Predicted)
Dichte
1.073±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
pka
11.14±0.46(Predicted)
Aggregatzustand
powder

Sicherheit

WGK Germany  3

(R)-MG132 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 μM (ChTL); 34.4 versus 104.43 μM (TL); 2.95 versus 5.70 μM (PGPH), respectively).

Verwenden

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

Biochem/physiol Actions

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

(R)-MG132 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(R)-MG132 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
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BOC Sciences
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TargetMol Chemicals Inc.
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Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
InvivoChem
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sales@invivochem.cn United States 6393 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763
sales@tnjchem.com China 25363 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24738 58

1211877-36-9()Verwandte Suche:


  • (R)-MG132
  • Cbz-L-leu-D-leu-L-leu-H
  • N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
  • MG-132(R)
  • benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
  • MG-132(S,R,S)
  • (S,R,S)-(-)-MG-132
  • Z-Leu-D-leu-leu-al
  • N-benzyloxycarbonyl-L-leucyl-D-leucyl-L-leucinal
  • NSC 60585
  • NSC60585
  • NSC-60585
  • D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-
  • Benzyl ((S)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)((S)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
  • 1211877-36-9
  • peptides
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