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GSK 2830371

GSK 2830371 Struktur
1404456-53-6
CAS-Nr.
1404456-53-6
Englisch Name:
GSK 2830371
Synonyma:
GSK 2830371;GSK 2830371 USP/EP/BP;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
CBNumber:
CB72682001
Summenformel:
C23H29ClN4O2S
Molgewicht:
461.02
MOL-Datei:
1404456-53-6.mol
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GSK 2830371 Eigenschaften

Siedepunkt:
704.1±60.0 °C(Predicted)
Dichte
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: soluble20mg/mL, clear
pka
13.29±0.46(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

GSK 2830371 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK 2830371 is used in biological studies as allosteric Wip1(wild-type p54-induced phosphatase) inhibition through flap-subdomain interaction.

Biochem/physiol Actions

GSK2830371 is an orally active allosteric inhibitor of wild-type p53-induced phosphatase (Wip1, also known as PPM1D/ PP2Cδ), an oncogenic type 2C serine/threonine phosphatase that negatively regulates key proteins in the DNA damage–response pathway. GSK2830371 is selective for Wip1 with an IC50 of 6 nM against Wip1 compared to >10 μM IC50 for PPM1A & PPM1K, and >30 μM IC50 for 22 other phosphatases tested. GSK2830371 is believed to interact with the flap subdomain located near the Wip1 catalytic site, a feature that distinguishes Wip1 from other members of the protein phosphatase 2C (PP2C) family. GSK2830371 increased phosphorylation of Wip1 substrates and caused growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

GSK 2830371 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,5-Dichloro-3-nitropyridine 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]- 3-Amino-5-chloropicoline (S)-tert-butyl (3-cyclopentyl-1-(cyclopropylaMino)-1-oxopropan-2-yl)carbaMate 5-Chloro-2-methyl-3-nitropyridine

Downstream Produkte

GSK 2830371 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 109)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd. 		18871490254
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Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
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InvivoChem 		+1-708-310-1919 +1-13798911105
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LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
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support@targetmol.com United States 19973 58
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 masar@topule.com China 8474 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 11013 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
  • GSK 2830371
  • 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide
  • (S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide
  • GSK 2830371 USP/EP/BP
  • 2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-
  • 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide
  • GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
  • 1404456-53-6
  • C23H29ClN4O2S
  • Inhibitors
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