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E6005

E6005 Struktur
947620-48-6
CAS-Nr.
947620-48-6
Englisch Name:
E6005
Synonyma:
E6005;CS-2517;RVT-501;lotamilast;E 6005;E-6005;RVT-501 E6005;E 6005: RVT-501;Lotamilast (RVT501;RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
CBNumber:
CB73170286
Summenformel:
C26H24N4O5
Molgewicht:
472.49
MOL-Datei:
947620-48-6.mol
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E6005 Eigenschaften

storage temp. 
Store at -20°C
Löslichkeit
DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
Aggregatzustand
A solid

Sicherheit

E6005 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.

Verwenden

RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).

E6005 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

E6005 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55
  • E6005
  • RVT-501
  • lotamilast
  • E 6005: RVT-501
  • METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
  • RVT-501 E6005
  • methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate
  • CS-2517
  • E 6005;E-6005
  • Benzoic acid, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-, methyl ester
  • Lotamilast (RVT501
  • RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit
  • 947620-48-6
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